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Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics.

作者信息

Yang Yushang, Li Yanguo, Yu Haopeng, Ding Zhenyu, Chen Longqi, Zeng Xiaoxi, He Shunmin, Liao Qi, Zhao Yi, Yuan Yong

机构信息

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.

出版信息

Signal Transduct Target Ther. 2023 Aug 11;8(1):298. doi: 10.1038/s41392-023-01518-0.

DOI:10.1038/s41392-023-01518-0
PMID:37563120
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10415278/
Abstract
摘要

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本文引用的文献

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Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment.整合单细胞转录组分析揭示食管鳞癌微环境的异质性。
Nat Commun. 2021 Dec 17;12(1):7335. doi: 10.1038/s41467-021-27599-5.
2
Dissecting the single-cell transcriptome network in patients with esophageal squamous cell carcinoma receiving operative paclitaxel plus platinum chemotherapy.剖析接受手术联合紫杉醇加铂类化疗的食管鳞状细胞癌患者的单细胞转录组网络。
Oncogenesis. 2021 Oct 26;10(10):71. doi: 10.1038/s41389-021-00359-2.
3
LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.
Understanding and overcoming multidrug resistance in cancer.
了解并克服癌症中的多药耐药性。
Nat Rev Clin Oncol. 2025 Jul 29. doi: 10.1038/s41571-025-01059-1.
4
DCF-resistant ESCC redevelops drug sensitivity when combined with calcium channel blockers due to ER stress response.对多西他赛和顺铂耐药的食管鳞癌在与钙通道阻滞剂联合使用时，由于内质网应激反应而重新产生药物敏感性。
Esophagus. 2025 Jul 10. doi: 10.1007/s10388-025-01146-3.
5
MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance.质谱细胞热位移分析深度功能蛋白质组学揭示导致吉西他滨耐药的DNA修复程序。
Nat Commun. 2025 May 7;16(1):4234. doi: 10.1038/s41467-025-59505-8.
6
Association between cancer-associated fibroblasts and prognosis of neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma: a bioinformatics analysis based on single-cell RNA sequencing.癌症相关成纤维细胞与食管鳞状细胞癌新辅助放化疗预后的关联：基于单细胞RNA测序的生物信息学分析
Cancer Cell Int. 2025 Mar 1;25(1):74. doi: 10.1186/s12935-025-03709-x.
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Cancer Med. 2025 Mar;14(5):e70730. doi: 10.1002/cam4.70730.
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Genome Med. 2024 Dec 18;16(1):148. doi: 10.1186/s13073-024-01422-4.
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J Immunother Cancer. 2023 Nov 28;11(11):e007847. doi: 10.1136/jitc-2023-007847.
LINCS Canvas 浏览器：交互式网络应用程序，用于查询、浏览和分析 LINCS L1000 基因表达特征。
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W449-60. doi: 10.1093/nar/gku476. Epub 2014 Jun 6.