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Single-cell sequencing of multi-region resolves geospatial architecture and therapeutic target of endothelial cells in esophageal squamous cell carcinoma.

作者信息

Dai Jiacheng, Xi Xiaoxiang, Liu Zidong, Wu Weicheng, Zhu Sibo, Zhang Xiaoyang, Huang Yuwei, Meng Jiayue, Yuan Liyun, Suo Chen, Xue Jiangli, Yuan Ziyu, Lv Ming, Ye Weimin, Jin Li, Zhang Guoqing, Chen Xingdong

机构信息

State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, School of Life Science, Fudan University, Shanghai, China.

Taixing People's Hospital, Taizhou, China.

出版信息

Clin Transl Med. 2023 Nov;13(11):e1487. doi: 10.1002/ctm2.1487.

DOI:10.1002/ctm2.1487
PMID:37987158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10660795/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/897e/10660795/b5c003ae0417/CTM2-13-e1487-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/897e/10660795/0e11c5eaa912/CTM2-13-e1487-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/897e/10660795/3383c5a5df5c/CTM2-13-e1487-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/897e/10660795/47895a9d6a3b/CTM2-13-e1487-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/897e/10660795/b5c003ae0417/CTM2-13-e1487-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/897e/10660795/0e11c5eaa912/CTM2-13-e1487-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/897e/10660795/3383c5a5df5c/CTM2-13-e1487-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/897e/10660795/47895a9d6a3b/CTM2-13-e1487-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/897e/10660795/b5c003ae0417/CTM2-13-e1487-g002.jpg

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本文引用的文献

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Nat Rev Cancer. 2023 Aug;23(8):544-564. doi: 10.1038/s41568-023-00591-5. Epub 2023 Jun 22.
2
Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast.单细胞图谱鉴定健康和恶性乳腺中的脂质处理和免疫调节内皮细胞。
Nat Commun. 2022 Sep 20;13(1):5511. doi: 10.1038/s41467-022-33052-y.
3
The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates From GLOBOCAN 2020.
2020年食管鳞状细胞癌和食管腺癌发病率及死亡率的全球格局以及至2040年的预测：来自GLOBOCAN 2020的新估计
Gastroenterology. 2022 Sep;163(3):649-658.e2. doi: 10.1053/j.gastro.2022.05.054. Epub 2022 Jun 4.
4
Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis.单细胞转录组分析解析食管鳞状细胞癌生态系统。
Nat Commun. 2021 Sep 6;12(1):5291. doi: 10.1038/s41467-021-25539-x.
5
Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing.多区域单细胞测序解析肺腺癌的空间和细胞结构。
Cancer Discov. 2021 Oct;11(10):2506-2523. doi: 10.1158/2159-8290.CD-20-1285. Epub 2021 May 10.
6
Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment.人类食管鳞状细胞癌微环境中的免疫抑制景观。
Nat Commun. 2020 Dec 8;11(1):6268. doi: 10.1038/s41467-020-20019-0.
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Gastroenterology. 2020 Oct;159(4):1311-1327.e19. doi: 10.1053/j.gastro.2020.06.050. Epub 2020 Jun 30.
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