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[抗抑郁药对氨基硫脲、士的宁和可拉索的惊厥作用的影响]

[Effect of antidepressants on the convulsive action of thiosemicarbazide, strychnine and corasol].

作者信息

Golovina S M, Andreeva N I

出版信息

Biull Eksp Biol Med. 1986 Sep;102(9):290-2.

PMID:3756328
Abstract

Orally administered amitryptiline (25 and 50 mg/kg) protected animals against fatal convulsions induced by thiosemicarbazide, strychnine and metrazole. Vilaxazine had a protecting effect against death induced by strychnine. Impramine, maprotiline, mianserine and pirlindole (pyrazidol) only somewhat prolonged the latend period of convulsions and death, while incazane, caroxazone, nomifenzine and trazodone had practically no effect on the action of the three convulsants under study.

摘要

口服阿米替林(25和50毫克/千克)可保护动物免受硫代氨基脲、士的宁和戊四氮诱发的致命惊厥。维拉佐嗪对士的宁诱发的死亡有保护作用。丙咪嗪、马普替林、米安色林和吡吲哚(吡唑醇)仅略微延长惊厥和死亡的潜伏期,而卡马西平、卡罗沙酮、诺米芬辛和曲唑酮对所研究的三种惊厥剂的作用几乎没有影响。

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