Shtrygol' D V, Shtrygol' S Iu
Eksp Klin Farmakol. 1995 Jan-Feb;58(1):22-5.
Murine experiments have demonstrated that excess sodium chloride intake has an aggravating effect on the course of convulsions caused by corazolum, thiosemicarbaside and maximum electric shock rather than strychnine. The new sodium chloride substitute hyposol given to animals ad libitum for a fortnight produces an anticonvulsant effect which is more pronounced in corazolum-induced convulsions and potentiates the anticonvulsant effect of diazepam. The official drug sanasol is antagonistic to strychnine and corazolum, but it displays a proconvulsant activity on a thiosemicarbaside model.
小鼠实验表明，过量摄入氯化钠会加重由柯拉佐林、硫代氨基脲和最大电击而非士的宁引起的惊厥过程。给动物随意喂食两周的新型氯化钠替代品低渗溶液会产生抗惊厥作用，在柯拉佐林诱导的惊厥中更为明显，并增强地西泮的抗惊厥作用。官方药物萨纳索尔对士的宁和柯拉佐林有拮抗作用，但在硫代氨基脲模型上显示出惊厥活性。
