Department of Internal Medicine and Hematology, Semmelweis University, Budapest, 1088, Hungary.
Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, Budapest, 1083, Hungary.
Sci Rep. 2023 Aug 10;13(1):12985. doi: 10.1038/s41598-023-40216-3.
Type 2 diabetes mellitus (T2DM) is a progressive disease, which affects colorectal cancer (CRC) survival. However, data on the relationship between CRC survival and T2DM duration is scarce and controversial. A retrospective observational study was conducted. Sub-cohorts were created based on the duration of T2DM as follows, ≤ or > 5/10/15/20 years. 204 of the 817 (24.95%) included study participants had T2DM at any point of CRC. 160 of the 204 CRC + T2DM patients had detailed T2DM duration data. At the time of CRC diagnosis, 85, 50, 31, and 11 patients had T2DM for > 5/10/15/20 years, respectively, which increased to 110, 71, 45, and 17 during the course of the study. Despite constant glycated hemoglobin values throughout the study, shorter overall and disease-specific survival times were observed for the > 5/10/15 years cohorts and longitudinal survival modeling techniques confirmed the significant effect of T2DM duration in all cohorts. While in the first 3 years after CRC diagnosis, the best survival was found for the ≤ 5 years cohort, all diabetes cohorts had the same survival thereafter. T2DM duration affected CRC survival significantly, therefore, a closer follow-up of this sub-populations is suggested.
2 型糖尿病（T2DM）是一种进行性疾病，会影响结直肠癌（CRC）的生存。然而，关于 CRC 生存与 T2DM 病程之间关系的数据仍然存在争议。本研究进行了一项回顾性观察性研究。根据 T2DM 病程创建了亚队列，具体如下：≤5 年、>5-10 年、>10-15 年和>15-20 年。在 817 名研究参与者中，有 204 名（24.95%）在 CRC 发病时患有 T2DM。在这 204 名 CRC+T2DM 患者中，有 160 名患者有详细的 T2DM 病程数据。在 CRC 诊断时，分别有 85、50、31 和 11 名患者患有 T2DM 超过 5 年、10 年、15 年和 20 年，在研究过程中，分别增加到 110、71、45 和 17 名。尽管整个研究过程中的糖化血红蛋白值保持不变，但>5 年、>10 年和>15 年的队列的总生存期和疾病特异性生存期更短，纵向生存模型技术证实了 T2DM 病程在所有队列中的显著影响。虽然在 CRC 诊断后的前 3 年内，≤5 年的队列生存最好，但此后所有糖尿病队列的生存情况相同。T2DM 病程显著影响 CRC 生存，因此建议对这一亚人群进行更密切的随访。
