[Effect of chronic administration of ethanol on the blood-brain barrier permeability of 14C-tyrosine and horseradish peroxidase in rats].

Chronic 10-days oral ethanol administration in doses 8-11 g/kg per day has been shown to increase blood-brain barrier penetration for peripherally administered 14C-tyrosine in Wistar heavy- and light-drinker rats. No changes in BBB permeability for horseradish peroxidase has been found. Chronic effect of ethanol on BBB systems of specific and unspecific transport in rats heavy- and light-drinkers is discussed.