[单次给予乙醇对血脑屏障对14C-酪氨酸、14C-多巴和辣根过氧化物酶通透性的影响]
[Effect of a single ethanol administration on the permeability of the hemato-encephalic barrier for 14C-tyrosine, 14C-DOPA and horseradish peroxidase].
作者信息
Burov Iu V, Borisenko S A, Kiianmaa K, Lehtosalo J, Mannisto P
出版信息
Biull Eksp Biol Med. 1986 Mar;101(3):331-4.
PMID:3082384
Abstract
Single injection of ethanol at a dose of 2 and 4 g/kg has been shown to increase blood-brain barrier penetration for peripherally administered 14C-tyrosine and 14C-DOPA. No changes in blood-brain barrier penetration for horseradish peroxidase has been found. Acute effect of ethanol on blood-brain barrier systems of specific and nonspecific transport is discussed.
摘要
已表明，单次注射剂量为2克/千克和4克/千克的乙醇可增加外周给予的14C-酪氨酸和14C-多巴的血脑屏障通透性。未发现辣根过氧化物酶的血脑屏障通透性有变化。讨论了乙醇对特异性和非特异性转运血脑屏障系统的急性影响。
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