Shishkina L N, Kolosova N G, Maianskiĭ D N
Biull Eksp Biol Med. 1986 Sep;102(9):319-21.
Zymosan granules injected intravenously (100 mg per kg of body weight) to Wistar rats induced strong stimulation of mononuclear phagocyte system. On day 5 zymosan-induced recruitment of monocyte-like cells with high consuming and bactericidal activity into lung spaces could be observed. Using fluorescent probes, it was discovered that the size of alveolar cell membranes in zymosan-stimulated or non-stimulated animals was similar, while the viscosity of membrane lipids of alveolar macrophages was considerably lower in zymosan-stimulated rats. These variations are suggested to be responsible for antiinflammatory and bactericidal macrophage potentials.
给Wistar大鼠静脉注射酵母聚糖颗粒（每千克体重100毫克）可强烈刺激单核吞噬细胞系统。在第5天，可以观察到酵母聚糖诱导具有高吞噬和杀菌活性的单核细胞样细胞募集到肺间隙。使用荧光探针发现，酵母聚糖刺激或未刺激动物的肺泡细胞膜大小相似，而酵母聚糖刺激的大鼠中肺泡巨噬细胞膜脂质的粘度明显较低。这些变化被认为是巨噬细胞抗炎和杀菌潜能的原因。
