Benichou G, Dormont D, Herodin F, Pasquier C
Centre de Recherches du Service de Santé des Armées, Clamart.
C R Acad Sci III. 1988;306(12):357-62.
The capacity of Guinea Pig alveolar macrophages to produce oxygenated free radicals after in vitro gamma irradiation was studied. We observed an increase of resting cell chemiluminescence with 3 Gy, then an important decrease from 3 Gy to 30 Gy. Chemiluminescence of zymosan activated macrophages was reduced at 10 Gy and 30 Gy, while activation by IgG anti-MHC antigens was not affected by the same radiation doses. These results could be of great interest for the study pulmonary defense mechanisms after irradiation.
研究了豚鼠肺泡巨噬细胞在体外γ射线照射后产生氧化自由基的能力。我们观察到，3戈瑞剂量照射后静息细胞化学发光增加，然后从3戈瑞到30戈瑞显著下降。酵母聚糖激活的巨噬细胞的化学发光在10戈瑞和30戈瑞剂量下降低，而抗MHC抗原IgG激活不受相同辐射剂量的影响。这些结果对于研究辐射后肺部防御机制可能具有重要意义。
