Leskova G F, Klimenko E D
Biull Eksp Biol Med. 1986 Sep;102(9):368-71.
Functional and morphological changes in the intestinal wall and liver were studied in rabbits on short-term cholesterol diet. It was established that with a rapid increase of cholesterol concentration in the general blood flow, the synthesis of high density lipoproteins in the intestinal wall was intensified. Enhanced hepatic elimination of cholesterol and chylomicrons from blood circulation contributes to cholesterol level stabilization in peripheral blood. With high density lipoprotein accumulation in the intestinal wall, cholesterol consumption did not change its concentration in the general blood flow. Structural changes in jejunal and liver mucosa were shown to depend on the degree of hypercholesterolemia and functional damage of these organs.
对短期食用胆固醇饮食的兔子的肠壁和肝脏的功能及形态变化进行了研究。结果表明，随着全身血流中胆固醇浓度的迅速增加，肠壁中高密度脂蛋白的合成增强。肝脏从血液循环中增强清除胆固醇和乳糜微粒有助于外周血中胆固醇水平的稳定。随着高密度脂蛋白在肠壁中的积累，胆固醇的消耗并未改变其在全身血流中的浓度。空肠和肝脏黏膜的结构变化显示取决于高胆固醇血症的程度以及这些器官的功能损害。
