Lebedev N N, Martsevich M S, Klimenko E D, Leskova G F, Kranchev A K
Biull Eksp Biol Med. 1983 Nov;96(11):16-20.
Functional and structural changes that occurred in the small intestine and liver of rabbits with alimentary hypercholesterolemia have been studied. Maximal rise of peripheral blood cholesterol after a single exposure to cholesterol was coupled with an increased penetration of chylomicrons and low and very low density lipoproteins from the intestine to the circulation. The decrease of cholesterol excretion along the whole length of the small intestine was accompanied by activation of the release of high density lipoproteins into the blood outflowing from the intestine. The decay of chylomicrons in the liver was restricted during the first days of hypercholesterolemia. Cholesterol concentration in the bile was decreased. The microvessels of the small intestine demonstrated the dilatation of the postcapillary-venular component erythrocyte aggregates and capillarostases.
对患有营养性高胆固醇血症的兔子的小肠和肝脏中发生的功能和结构变化进行了研究。单次接触胆固醇后外周血胆固醇的最大升高与乳糜微粒以及低密度和极低密度脂蛋白从肠道向循环系统的渗透性增加有关。小肠全长胆固醇排泄的减少伴随着高密度脂蛋白释放到从肠道流出的血液中的激活。在高胆固醇血症的最初几天，肝脏中乳糜微粒的分解受到限制。胆汁中的胆固醇浓度降低。小肠的微血管显示出毛细血管后静脉成分红细胞聚集和毛细血管停滞的扩张。
