LLC "MATERIA MEDICA HOLDING", Moscow, Russia.
Bull Exp Biol Med. 2023 Jul;175(3):327-330. doi: 10.1007/s10517-023-05861-8. Epub 2023 Aug 11.
High dilutions of solutions containing extremely small amounts of the initial substance can modify the biological effects of the initial substance molecules. Using terahertz spectroscopy, we studied the possibility of modifying the physicochemical properties of the initial substance by adding high dilutions of high-molecular-weight (IFNγ) and low-molecular-weight (Na2SO4) compounds. In addition, the modifying effect produced by high dilutions of a low-molecular electrolyte (a solution of NaSO salt) on the initial substance was confirmed by conductometry. This method allows measuring electrical conductivity that also depends on the physicochemical properties of the solution, namely, the number of ions and velocity of their movement. Statistically significant differences were shown between terahertz and conductometric characteristics of the initial solution (inorganic salt Na2SO4 or a protein IFNγ) and a solution, where high dilutions of the same substances were added in different concentrations. Interestingly, the differences were more pronounced for the biological molecule. Thus, it has been shown that high dilutions can change the properties of the initial solution; the effect is more pronounced for the protein solution.
高稀释度的溶液，其中含有极少量的初始物质，可以改变初始物质分子的生物学效应。我们使用太赫兹光谱法研究了通过添加高分子量（IFNγ）和低分子量（Na2SO4）化合物的高稀释度来改变初始物质的物理化学性质的可能性。此外，通过电导率法证实了低分子量电解质（NaSO 盐溶液）的高稀释度对初始物质产生的修饰作用。该方法允许测量电导率，电导率也取决于溶液的物理化学性质，即离子的数量及其运动速度。初始溶液（无机盐 Na2SO4 或蛋白质 IFNγ）和添加了相同物质的高稀释度的溶液的太赫兹和电导率特性之间表现出统计学上的显著差异。有趣的是，对于生物分子，差异更为明显。因此，已经表明高稀释度可以改变初始溶液的性质；对于蛋白质溶液，效果更为明显。
