Department of Population Health Sciences, University of Leicester, Leicester, UK.
IRSS, Catholic University of Louvain, Brussels, 1200, Belgium.
Health Qual Life Outcomes. 2023 Aug 10;21(1):85. doi: 10.1186/s12955-023-02172-4.
Vitiligo is reported to affect 2% of the world's population and has a significant impact on health related quality of life (HRQoL). The relationship between HRQoL and clinical outcomes used in vitiligo require further examination. Mapping condition specific measures of HRQoL: vitiligo specific quality of life instrument (VitiQoL), vitiligo noticeability scale (VNS) and vitiligo re-pigmentation scores (RPS) to the EQ-5D have not yet been reported.
Data collected from a randomised clinical trial (HI-Light) in vitiligo was used to develop mapping algorithms for the EQ-5D-5 L and the relationship between HRQoL, clinical outcomes and EQ-5D were investigated. Two EQ-5D-5 L value sets (Van Hout and Alava) using linear and non-linear models were considered. Logistic regression models were used to model the probability of vitiligo noticeability (VNS) in terms of RPS, EQ-5D and VitiQoL scores.
Mapping from RPS appeared to perform better followed by VNS for the Alava crosswalks using polynomial models: Mean observed vs. predicted utilities of 0.9008 (0.005) vs. 0.8984 (0.0004) were observed for RPS. For VNS, mean observed vs. predicted utilities of 0.9008 (0.005) vs. 0.8939 (0.0003) were observed. For VitiQoL, mean observed vs. predicted utilities of 0.9008 (0.005) vs. 0.8912 (0.0002) were observed. For patients with the least re-pigmentation (RPS < 25%), a Total VitiQoL score of about 20 points gives around an 18% chance of vitiligo being no longer or a lot less noticeable.
The algorithm based on RPS followed by VNS performed best. The relationship between effects from vitiligo specific HRQoL instruments and clinical RPS was established allowing for plausible clinically relevant differences to be identified, although further work is required in this area.
据报道，白癜风影响世界人口的 2%，对健康相关生活质量（HRQoL）有重大影响。白癜风患者的 HRQoL 与临床结果之间的关系需要进一步研究。将特定于疾病的 HRQoL 测量指标（白癜风生活质量量表（VitiQoL）、白癜风可见性量表（VNS）和白癜风再色素沉着评分（RPS）映射到 EQ-5D 尚未报道。
使用来自白癜风随机临床试验（HI-Light）的数据开发 EQ-5D-5L 映射算法，并研究 HRQoL、临床结果和 EQ-5D 之间的关系。考虑了两种 EQ-5D-5L 值集（Van Hout 和 Alava），使用线性和非线性模型。使用逻辑回归模型根据 RPS、EQ-5D 和 VitiQoL 评分来建模白癜风可见性（VNS）的概率。
对于 Alava 交叉映射，使用多项式模型，RPS 似乎比 VNS 表现更好：观察到的平均与预测效用分别为 0.9008（0.005）和 0.8984（0.0004）。对于 VNS，观察到的平均与预测效用分别为 0.9008（0.005）和 0.8939（0.0003）。对于 VitiQoL，观察到的平均与预测效用分别为 0.9008（0.005）和 0.8912（0.0002）。对于再色素沉着最少的患者（RPS < 25%），总 VitiQoL 评分约为 20 分，大约有 18%的机会使白癜风不再或明显减轻。
基于 RPS 随后是 VNS 的算法表现最佳。建立了白癜风特定 HRQoL 工具和临床 RPS 之间的关系，允许确定合理的临床相关差异，尽管在这方面还需要进一步的工作。
