Graif M, Steiner R E
Br J Radiol. 1986 Sep;59(705):865-73. doi: 10.1259/0007-1285-59-705-865.
The clinical application of the intravascular paramagnetic contrast agent gadolinium-DTPA for magnetic resonance imaging (MRI) imaging of tumours of the central nervous system (CNS) has been assessed over the past 3 years. Various patterns of contrast enhancement were observed, and situations in MRI where the administration of contrast medium may be useful have been defined. These include lesions which are isointense with normal brain matter, the separation of tumour from surrounding oedema, evaluation of the degree of blood-brain barrier breakdown, delineation of tumours obscured by overlying calcification on computed tomography (CT) and in the investigation of lesions in anatomical areas where CT has known limitations (brain stem, cervical spine). Changes in relaxation times in normal and abnormal tissues following contrast medium, toxicity and dosage of gadolinium-DTPA, and MRI pulse sequence techniques are reviewed.
在过去3年中，对血管内顺磁性造影剂钆-二乙三胺五醋酸（gadolinium-DTPA）用于中枢神经系统（CNS）肿瘤的磁共振成像（MRI）的临床应用进行了评估。观察到了各种造影剂增强模式，并确定了在MRI中使用造影剂可能有用的情况。这些情况包括与正常脑实质等信号的病变、肿瘤与周围水肿的区分、血脑屏障破坏程度的评估、计算机断层扫描（CT）上被覆盖钙化掩盖的肿瘤的描绘，以及在CT有已知局限性的解剖区域（脑干、颈椎）的病变研究。回顾了造影剂注入后正常和异常组织中弛豫时间的变化、钆-二乙三胺五醋酸的毒性和剂量以及MRI脉冲序列技术。
