Li Naijian, Quan Sicui, Liu Qin, Xie Zhiling, Wang Qiong, Wang Nian, Wang Jinlin
Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Pathology, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Front Med (Lausanne). 2023 Jul 26;10:1209491. doi: 10.3389/fmed.2023.1209491. eCollection 2023.
Minute pulmonary meningothelial-like nodules (MPMNs) and diffuse pulmonary meningotheliomatosis (DPM) are both rare lung diseases that involve the proliferation of cells of meningothelial origin in the lungs. However, few studies have focused on the clinical, pathological, and radiological features of MPMNs and DPMs.
The clinicopathological data of 167 cases diagnosed as MPMNs and 13 cases diagnosed as DPM in the China National Center for Respiratory Medicine were examined. Based on clinical data, CT images, and morphological features, this study analyzed the similarities and differences between MPMNs and DPM.
The detection rates of MPMNs and DPM were 1.9 and 0.15%, respectively. Compared to MPMNs, DPM patients were all women (100% vs. 79.4%, = 0.066), had a younger age (51.4 ± 7.7 vs. 57.9 ± 8.5, < 0.01), and had higher pulmonary function ( < 0.01 or < 0.05). The chest CT of DPM patients showed diffuse ground-glass opacity nodules measuring 2.0-8.0 mm in diameter, with the number of nodules ranging from 40 to >600 per lung. There were no significant differences in nodule volume [28.0 (12.1, 65.1) mm vs. 28.7 (17.1, 48.9) mm, = 0.451] and CT values [-646.8 (-732.5, -514.5) Hu vs. -588 (-674, -480) Hu, = 0.215] between MPMNs and DPM. MPMNs are characterized by reactive hyperplasia pulmonary nodules, which can be solitary or multiple.
This study suggests that there are many different characteristics between patients with MPMNs and DPM. The limited findings challenge the notion that DPM is a rare subtype of MPMNS.
微小肺脑膜上皮样结节（MPMNs）和弥漫性肺脑膜瘤病（DPM）均为罕见的肺部疾病，涉及肺内脑膜上皮起源细胞的增殖。然而，很少有研究关注MPMNs和DPM的临床、病理及影像学特征。
对中国国家呼吸医学中心诊断为MPMNs的167例病例及诊断为DPM的13例病例的临床病理资料进行分析。基于临床数据、CT图像及形态学特征，本研究分析了MPMNs和DPM之间的异同。
MPMNs和DPM的检出率分别为1.9%和0.15%。与MPMNs相比，DPM患者均为女性（100%对79.4%，P = 0.066），年龄更小（51.4±7.7对57.9±8.5，P<0.01），肺功能更好（P<0.01或P<0.05）。DPM患者的胸部CT显示直径为2.0 - 8.0 mm的弥漫性磨玻璃样结节，每侧肺内结节数量为40至>600个。MPMNs和DPM在结节体积[28.0（12.1，65.1）mm对28.7（17.1，48.9）mm，P = 0.451]和CT值[-646.8（-732.5，-514.5）Hu对-588（-674，-480）Hu，P = 0.215]方面无显著差异。MPMNs以反应性增生性肺结节为特征，可为单发或多发。
本研究表明，MPMNs和DPM患者存在许多不同特征。这些有限的发现对DPM是MPMNs的罕见亚型这一观点提出了挑战。
