Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Rd, Shanghai, 200032, China.
Institute of Thoracic Oncology, Fudan University, Shanghai, 200032, China.
J Cancer Res Clin Oncol. 2022 Jun;148(6):1473-1479. doi: 10.1007/s00432-021-03744-x. Epub 2021 Jul 21.
Reports about the radiologic features of minute pulmonary meningothelial-like nodules are sparse. This study aims to investigate the radiologic features of minute pulmonary meningothelial-like nodules.
From January 2016 to April 2019, 7589 patients underwent pulmonary resections at Fudan University Shanghai Cancer Center. Postoperative pathology records were reviewed retrospectively. Fifty-nine patients with minute pulmonary meningothelial-like nodule were included. The identification of minute pulmonary meningothelial-like nodules in pathology specimen included pathologically confirmed in resected nodules, and discovery in the peripheral tissue of other resected nodules incidentally. We went back and checked all the pre-operative scans of patients to analyze surgical decision and observe any change of visible minute pulmonary meningothelial-like nodule over time. Clinic, radiologic and pathological features were collected.
Fifty-nine patients included 10 men and 49 women, with a mean age of 57.7. Five patients had history, while 54 patients were non-smokers. 79 min pulmonary meningothelial-like nodules was found. Of them, 36 nodules were not visible on computed tomography scan. 43 nodules were visible on computed tomography scan, with an average size of 5.3 mm in 29 patients. Computed tomography appearance included pure ground-glass opacity in 36, mixed in 2, and solid nodules in 5. Nearly half of patients had a pre-operative follow-up more than 6 months (13/29, 44.8%). The median pre-operative radiologic follow-up was 4.9 months. Approximately 90% of patients underwent pulmonary surgery because of other malignant nodule on chest computed tomography scan (52/59, 88.1%).
Most minute pulmonary meningothelial-like nodules tend to present as ground-glass opacity, especially pure ground-glass opacity. Continuous computed tomography monitoring revealed no radiologic change over time. Continuous computed tomography monitoring was necessary part of management of minute pulmonary meningothelial-like nodule.
关于微小肺脑膜瘤样结节的放射学特征的报道很少。本研究旨在探讨微小肺脑膜瘤样结节的放射学特征。
本研究回顾性分析了 2016 年 1 月至 2019 年 4 月在复旦大学附属肿瘤医院接受肺切除术的 7589 例患者的术后病理记录。纳入 59 例微小肺脑膜瘤样结节患者。病理标本中微小肺脑膜瘤样结节的鉴定包括切除结节中经病理证实的结节，以及偶然在其他切除结节的周围组织中发现的结节。我们回顾了所有患者的术前扫描，以分析手术决策，并观察可见的微小肺脑膜瘤样结节随时间的变化。收集了临床、放射学和病理学特征。
59 例患者中男 10 例，女 49 例，平均年龄 57.7 岁。5 例有病史，54 例为不吸烟患者。共发现 79 个微小肺脑膜瘤样结节。其中，36 个结节在 CT 扫描上不可见。43 个结节在 CT 扫描上可见，29 例患者的平均直径为 5.3mm。CT 表现包括纯磨玻璃密度影 36 例，混合性 2 例，实性结节 5 例。近一半的患者（13/29，44.8%）的术前随访时间超过 6 个月。中位术前放射学随访时间为 4.9 个月。大约 90%的患者（52/59，88.1%）因胸部 CT 扫描上其他恶性结节而行肺手术。
大多数微小肺脑膜瘤样结节倾向于表现为磨玻璃影，尤其是纯磨玻璃影。连续 CT 监测显示随时间无放射学变化。连续 CT 监测是微小肺脑膜瘤样结节管理的必要组成部分。
