Samimi Soroush, Abbasi Saeed, Taheri Azadeh, Farsaei Shadi
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Anesthesiology and Critical Care, Anesthesiology and Critical Care Research Center, Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2023 Jun 30;12:168. doi: 10.4103/abr.abr_302_22. eCollection 2023.
High prevalence of pressure ulcers (PUs) and their complications are important dilemmas in the intensive care unit (ICU). Therefore this study was designed to evaluate the effectiveness of topical whey protein formulation in preventing PUs in patients admitted to the ICU.
In this randomized placebo-controlled clinical trial under registration number [IRCTdeted for blinded article], 80 eligible ICU patients were randomly allocated to receive topical ointment of whey protein or placebo on the sacrum with a diameter of 15 cm twice daily for seven days, in addition to the routine care. The mean risk score for developing PUs was calculated at baseline using the Braden tool, and the PUSH score was used to assess PUs on days 4, 7, and 14. Patients' related demographic and clinical variables were also collected using a medical record for more evaluation.
Our results showed that demographic characteristics and the Braden scores' baseline mean were not significantly different between groups ( > 0.05). The repeated measures ANOVA test revealed that the mean scores of PUs at various times were markedly lower in the whey protein than in the placebo group ( < 0.001).
This intervention can be routinely added as effective, safe, inexpensive, and accessible care to reduce the incidence of PUs for patients at risk of developing this injury.
压疮（PU）的高发生率及其并发症是重症监护病房（ICU）中的重要难题。因此，本研究旨在评估局部应用乳清蛋白制剂对预防入住ICU患者发生压疮的有效性。
在这项注册号为[IRCTdeted for blinded article]的随机安慰剂对照临床试验中，80名符合条件的ICU患者被随机分配，除常规护理外，每天两次在直径为15厘米的骶骨部位涂抹乳清蛋白或安慰剂软膏，持续7天。使用Braden工具在基线时计算发生压疮的平均风险评分，并在第4、7和14天使用PUSH评分评估压疮情况。还通过病历收集患者相关的人口统计学和临床变量，以进行更多评估。
我们的结果表明，两组之间的人口统计学特征和Braden评分的基线平均值无显著差异（>0.05）。重复测量方差分析显示，乳清蛋白组不同时间的压疮平均评分明显低于安慰剂组（<0.001）。
这种干预措施可作为有效、安全、廉价且易于获得的护理常规添加，以降低有发生此类损伤风险的患者发生压疮的发生率。
