Elliott P J, Chan J, Parker Y M, Nemeroff C B
Brain Res. 1986 Sep 3;381(2):259-65. doi: 10.1016/0006-8993(86)90075-2.
The behavioral effects of intracerebroventricularly administered neurotensin (NT), some NT fragments and two synthetic NT analogs were investigated in the open field. Each peptide was studied in both a 'novel' (no pre-exposure) and a 'familiar' (with pre-exposure) environmental situation. Neurotensin decreases locomotor activity in the periphery but increases the time spent in the central area of the apparatus. Of the congeners tested, D-Phe11-NT has similar effects to NT whereas the NT fragments were generally inactive. These findings indicate that the intact peptide or stable substituted NT analogs, but not small C- and N-terminal fragments of NT, are behaviorally active after intraventricular administration.
在旷场实验中研究了脑室内注射神经降压素（NT）、一些NT片段及两种合成NT类似物的行为学效应。每种肽分别在“新环境”（无预暴露）和“熟悉环境”（有预暴露）两种情况下进行研究。神经降压素在外周降低运动活性，但增加在实验装置中央区域停留的时间。在所测试的同类物中，D-苯丙氨酸11-神经降压素与神经降压素具有相似效应，而NT片段通常无活性。这些发现表明，完整肽或稳定取代的NT类似物（而非NT的小C末端和N末端片段）在脑室内给药后具有行为学活性。
