Lorke D E, Winking H
Brain Res Bull. 1986 Jun;16(6):845-51. doi: 10.1016/0361-9230(86)90080-8.
Retinal development of trisomy 19 (Ts19) mice has been studied by microscopy from postnatal day 2 (PD 2) to PD 15. Gross malformations of the eye or alterations of the cellular arrangement are not detectable; retinal differentiation follows the regular pattern observed in chromosomally balanced control littermates. At all stages examined, the development of the retina in Ts19 lags approximately 2 days behind littermate controls. The maturation of all cellular constituents examined is retarded to the same degree. Appearance of the outer plexiform layer, cessation of mitotic activity, penetration of blood vessels in the nerve fiber layer and in the outer plexiform layer, differentiation of the inner granular layer and receptor formation are each delayed about two days. On a cellular level, there is no indication for an asynchronous development in the retina of Ts19. In addition to the retarded maturation, the diameters of the eyes are reduced in Ts19 mice.
通过显微镜检查，对19三体（Ts19）小鼠从出生后第2天（PD 2）到PD 15的视网膜发育情况进行了研究。未检测到眼睛的明显畸形或细胞排列的改变；视网膜分化遵循在染色体平衡的同窝对照小鼠中观察到的正常模式。在所有检查阶段，Ts19小鼠视网膜的发育比同窝对照小鼠落后约2天。所检查的所有细胞成分的成熟均受到同等程度的延迟。外丛状层的出现、有丝分裂活动的停止、血管在神经纤维层和外丛状层的穿透、内颗粒层的分化以及感受器的形成均延迟约两天。在细胞水平上，没有迹象表明Ts19小鼠视网膜存在异步发育。除了成熟延迟外，Ts19小鼠的眼睛直径也减小了。
