Lorke D E, Engelmann E
Abteilung für Neuroanatomie, Universitäts-Krankenhaus Eppendorf, Hamburg, BRD.
Acta Anat (Basel). 1988;131(1):56-65.
To investigate the development of the retinal layers, the eyes of mice with trisomy 19 have been examined by light microscopy between the 2nd and 15th postnatal day. The diameter of the eye, thickness of the entire retina and both relative thickness and nuclear density of each of the retinal layers have been measured and compared to those of chromosomally balanced control animals. Malformations of the eye, alterations of cell morphology or disturbed lamination can not be observed. Retinal differentiation of trisomy 19 mice is delayed by approximately two days. The development of all cellular constituents, i.e., of both neuroectodermal and mesenchymal origin, is retarded accordingly. The eyes of trisomy 19 mice are of reduced size. The relative thickness of each retinal layer follows a normal growth pattern; there is no indication for a selective impairment of the development of one particular layer. With the exception of the ganglion cell layer, nuclear densities of each retinal layer do not differ from those of control mice. The comparison of nuclear densities in the ganglion cell layer suggests that in trisomy 19 mice fewer postmitotic cells differentiate into mature retinal cells.
为了研究视网膜各层的发育情况，在出生后第2天至第15天期间，通过光学显微镜对19三体小鼠的眼睛进行了检查。测量了眼睛的直径、整个视网膜的厚度以及每个视网膜层的相对厚度和核密度，并与染色体平衡的对照动物进行了比较。未观察到眼睛畸形、细胞形态改变或分层紊乱。19三体小鼠的视网膜分化延迟了约两天。所有细胞成分（即神经外胚层和间充质来源的细胞成分）的发育相应延迟。19三体小鼠的眼睛尺寸减小。每个视网膜层的相对厚度遵循正常的生长模式；没有迹象表明某一特定层的发育受到选择性损害。除神经节细胞层外，每个视网膜层的核密度与对照小鼠无差异。神经节细胞层核密度的比较表明，在19三体小鼠中，较少的有丝分裂后细胞分化为成熟的视网膜细胞。
