通过计算机断层扫描评估2019冠状病毒病患者皮下和内脏脂肪组织的变化，并与肺部受累的定量分析进行比较。

The evaluation of subcutaneous and visceral adipose tissue changes by computed tomography in coronavirus disease 2019 and comparison with quantitative analysis of lung involvement.

作者信息

Vural Murat, Akdal Dolek Betul, Ucar Ozgul, Ozkan Erdem, Eren Ozkaya Utku

机构信息

Ankara City Hospital, Department of Radiology, Ankara City Hospital, Universiteler Mahallesi 1604. Cadde, No: 9 Çankaya, Ankara 06800, Turkey.

Ankara City Hospital, Department of Radiology.

出版信息

Curr Med Imaging. 2023 Aug 10. doi: 10.2174/1573405620666230810093651.

DOI:10.2174/1573405620666230810093651

PMID:37565559

Abstract

BACKGROUND

This study aims to reveal the relationship between lung involvement and visceral adipose tissue changes between chest-computed tomography (CT) scans taken in short intervals in COVID-19 patients.

METHODS

The retrospective study included 52 patients who tested positive for SARS-CoV-2. All patients had two chest CT exams. Lung involvement measurements were calculated by using an artificial intelligence tool. Visceral and subcutaneous fat tissue was measured at the level of the first lumbar vertebra on chest CT. Additionally, demographic and laboratory data were collected.

RESULTS

52 patients were included (36.5 % female, mean age 50). Visceral fat area and visceral fat thickness changes were significantly positive predictors of total lung involvement changes (p=0.033, p=0.00024). Subcutaneous fat area and subcutaneous fat thickness changes were not associated with lung involvement change (p>0.05). CRP, IL-6, d-dimer, and ferritin levels were higher in patients who need intensive care units.

CONCLUSION

Visceral adipose tissue changes may indicate that it can have a role as a reservoir of virus involvement.

摘要

背景

本研究旨在揭示新型冠状病毒肺炎（COVID-19）患者短时间内胸部计算机断层扫描（CT）中肺部受累与内脏脂肪组织变化之间的关系。

方法

这项回顾性研究纳入了52例严重急性呼吸综合征冠状病毒2（SARS-CoV-2）检测呈阳性的患者。所有患者均进行了两次胸部CT检查。使用人工智能工具计算肺部受累程度。在胸部CT上第一腰椎水平测量内脏和皮下脂肪组织。此外，收集了人口统计学和实验室数据。

结果

纳入52例患者（女性占36.5%，平均年龄50岁）。内脏脂肪面积和内脏脂肪厚度变化是肺部总受累变化的显著正预测因子（p = 0.033，p = 0.00024）。皮下脂肪面积和皮下脂肪厚度变化与肺部受累变化无关（p>0.05）。需要重症监护病房的患者的C反应蛋白（CRP）、白细胞介素-6（IL-6）、D-二聚体和铁蛋白水平较高。