50 岁及 60 岁日本女性中大豆苷元和非酒精性脂肪肝的关系。
Association between equol and non-alcoholic fatty liver disease in Japanese women in their 50s and 60s.
机构信息
Department of Gastroenterology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
Institution for Total Medical Checkup, Jusendo Clinic, Fukushima, Japan.
出版信息
J Gastroenterol Hepatol. 2023 Nov;38(11):1958-1962. doi: 10.1111/jgh.16315. Epub 2023 Aug 10.
BACKGROUND AND AIM
Equol is a metabolite of soy isoflavone and has estrogenic activity. The incidence of non-alcoholic fatty liver disease (NAFLD) increases after menopause in women, which is thought to result in a decrease in estrogen. This study aimed to evaluate the association between equol and NAFLD.
METHODS
We evaluated 1185 women aged 50-69 years who underwent health check-ups at four health centers in Fukushima, Japan. Equol producers were defined by a urinary equol concentration of 1.0 μM or more. In addition to comparison between equol producers and non-producers, the association between equol and NAFLD was estimated using logistic regression analysis adjusting for fast walking and eating habits.
RESULTS
Of the 1185 participants, 345 (29.1%) women were equol producers. The proportions of women who had NAFLD (34.8% vs 45.2%) were significantly lower in the equol-producing group than in the non-producing group. Multivariable logistic regression analysis showed that equol production was significantly associated with NAFLD (odds ratio = 0.66, 95% confidence interval: 0.51-0.86).
CONCLUSIONS
Equol production was significantly associated with NAFLD in women in their 50s and 60s.
背景与目的
黄豆异黄酮的代谢产物雌马酚具有雌激素活性。女性绝经后，非酒精性脂肪性肝病（NAFLD）的发病率增加，这被认为是雌激素水平下降所致。本研究旨在评估雌马酚与 NAFLD 之间的关系。
方法
我们评估了日本福岛四个健康中心 1185 名年龄在 50-69 岁之间的女性。将尿液中雌马酚浓度达到 1.0μM 或以上的女性定义为雌马酚产生者。除了比较雌马酚产生者和非产生者之间的差异外，还通过多变量逻辑回归分析调整快走和饮食习惯，来评估雌马酚与 NAFLD 的关系。
结果
在 1185 名参与者中，有 345 名（29.1%）女性是雌马酚产生者。在雌马酚产生组中，患有 NAFLD 的女性比例（34.8%比 45.2%）明显低于非产生组。多变量逻辑回归分析显示，雌马酚产生与 NAFLD 显著相关（比值比=0.66，95%置信区间：0.51-0.86）。
结论
在 50 多岁和 60 多岁的女性中，雌马酚的产生与 NAFLD 显著相关。
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