Reisin E
Can J Physiol Pharmacol. 1986 Jun;64(6):818-24. doi: 10.1139/y86-141.
A number of studies have established a close association between increased body mass and elevated blood pressure. The presence of obesity in hypertensive subjects is associated with some hemodynamic, metabolic, and endocrinic characteristics: an increased intravascular volume with a high intracellular body water/interstitial fluid volume ratio, increased cardiac output, stroke volume, and left ventricular work while peripheral resistance was reduced or normal. Weight loss of at least 10 kg can reduce blood pressure independently of changes in sodium intake in obese persons of both sexes with mild, moderate, or severe high blood pressure. The fall in arterial pressure in obese hypertensives after weight loss may reverse many of the previously mentioned altered findings and underscore previous epidemiological studies that have shown that weight control could be an important measure in the treatment of hypertension.
多项研究已证实体重增加与血压升高之间存在密切关联。高血压患者中肥胖的存在与一些血液动力学、代谢和内分泌特征相关：血管内容量增加，细胞内体水/组织液体积比高，心输出量、每搏输出量和左心室做功增加，而外周阻力降低或正常。对于患有轻度、中度或重度高血压的男女肥胖者，体重至少减轻10公斤可独立于钠摄入量的变化而降低血压。肥胖高血压患者体重减轻后动脉压的下降可能会逆转许多上述改变的结果，并强调先前的流行病学研究表明，控制体重可能是治疗高血压的一项重要措施。
