Yin Zhengrong, Liu Yaxi, Anniwaer Annikaer, You Yuan, Guo Jingmei, Tang Ying, Fu Lei, Yi Luyao, Huang Cui
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
Adv Mater. 2023 Aug 11:e2305633. doi: 10.1002/adma.202305633.
Oral biofilms, which are also known as dental plaque, are the culprit of a wide range of oral diseases and systemic diseases, thus contributing to serious health risks. The manner of how to achieve good control of oral biofilms has been an increasing public concern. Novel antimicrobial biomaterials with highly controllable fabrication and functionalization have been proven to be promising candidates. However, previous reviews have generally emphasized the physicochemical properties, action mode, and application effectiveness of those biomaterials, whereas insufficient attention has been given to the design rationales tailored to different infection types and application scenarios. To offer guidance for better diversification and functionalization of anti-oral-biofilm biomaterials, this review details the up-to-date design rationales in three aspects: the core strategies in combating oral biofilm, as well as the biomaterials with advanced antibiofilm capacity and multiple functions based on the improvement or combination of the abovementioned antimicrobial strategies. Thereafter, insights on the existing challenges and future improvement of biomaterial-assisted oral biofilm treatments are proposed, hoping to provide a theoretical basis and reference for the subsequent design and application of antibiofilm biomaterials.
口腔生物膜，也被称为牙菌斑，是多种口腔疾病和全身性疾病的罪魁祸首，从而带来严重的健康风险。如何有效控制口腔生物膜一直是公众日益关注的问题。具有高度可控制造和功能化的新型抗菌生物材料已被证明是很有前景的候选材料。然而，以往的综述通常强调这些生物材料的物理化学性质、作用方式和应用效果，而对针对不同感染类型和应用场景的设计原理关注不足。为了为抗口腔生物膜生物材料的更好多样化和功能化提供指导，本综述从三个方面详细阐述了最新的设计原理：对抗口腔生物膜的核心策略，以及基于上述抗菌策略的改进或组合而具有先进抗生物膜能力和多种功能的生物材料。此后，针对生物材料辅助口腔生物膜治疗的现有挑战和未来改进提出了见解，希望为后续抗生物膜生物材料的设计和应用提供理论依据和参考。
