From the Naval Medical Center Portsmouth, Portsmouth, VA.
Clin Nucl Med. 2023 Oct 1;48(10):e487-e488. doi: 10.1097/RLU.0000000000004780. Epub 2023 Aug 3.
Skeletal fluorosis is more common in the developing world, but is occasionally seen in the United States. We present radiographic, scintigraphic, CT, and clinical images of a 26-year-old woman with rapidly progressive, debilitating, polyostotic periostitis, and diffuse osteosclerosis typical of skeletal fluorosis. Laboratory analyses supported this diagnosis. The source of excess fluoride intake was elusive until a concurrent mental health workup revealed the patient's proclivity for inhaling air-duster cans containing difluoroethane. Difluoroethane inhalant abuse is an increasingly reported cause of skeletal fluorosis that astute clinicians should recognize. Discontinuation and sobriety from this toxic agent are essential for recovery.
氟骨症在发展中国家更为常见，但偶尔也会出现在美国。我们呈现了一位 26 岁女性的影像学、闪烁扫描、CT 和临床图像，她患有进行性迅速、使人虚弱的多骨性骨膜炎和弥漫性骨硬化，这是氟骨症的典型表现。实验室分析支持这一诊断。直到同时进行的心理健康评估揭示了患者吸入含有二氟乙烷的空气清新剂罐的倾向，摄入过多氟化物的来源才变得难以捉摸。二氟乙烷吸入剂滥用是一种越来越多被报道的氟骨症病因，敏锐的临床医生应该认识到这一点。停止使用这种有毒物质并戒除毒瘾对于康复至关重要。
