From the Departments of Nuclear Medicine.
Pulmonology, Clínica Universidad de Navarra, Pamplona, Spain.
Clin Nucl Med. 2023 Oct 1;48(10):e494-e495. doi: 10.1097/RLU.0000000000004784. Epub 2023 Aug 3.
A 53-year-old man with persisting increased serum prostate-specific antigen level (9.53 ng/mL) and repeated negative prostate biopsies was referred for a PET/CT with 68 Ga-PSMA-11. The PET/CT revealed focal uptake in the prostate suggestive of localized prostate cancer. Incidentally, it also showed a diffuse uptake in the tracheobronchial tree suspicious for a benign etiology. Because of the clinical history of asthma exacerbation in the previous week, further supplementary studies were performed showing a pathological fractional exhaled nitric oxide level (92 ppb; reference values, <25 ppb) and mild airway obstruction in the spirometry. These findings confirmed asthma as an inflammatory etiology of the tracheobronchial PSMA uptake.
一位 53 岁男性，持续血清前列腺特异性抗原水平升高（9.53ng/mL），且前列腺重复活检均为阴性，遂进行 Ga-PSMA-11 PET/CT 检查。PET/CT 显示前列腺局灶性摄取，提示局限性前列腺癌。此外，气管支气管树也有弥漫性摄取，提示良性病因。由于前一周哮喘加重的临床病史，进一步进行了补充研究，显示呼出一氧化氮分数（92ppb；参考值<25ppb）升高和肺功能轻度气道阻塞。这些发现证实了哮喘是气管支气管 PSMA 摄取的炎症病因。
