Department of Radiology, Saint Louis University Hospital, St. Louis, Missouri;
Department of Radiology, Fred Hutchinson Cancer Center, University of Washington, Seattle, Washington.
J Nucl Med. 2024 Sep 3;65(9):1383-1386. doi: 10.2967/jnumed.124.267772.
We evaluated the incidence and potential etiology of tracheobronchial uptake in patients being evaluated by F-DCFPyL PET/CT for prostate cancer (PCa). The study included a consecutive 100 PCa patients referred for F-DCFPyL PET/CT. The PET/CT scans were retrospectively reviewed. The presence or absence of physiologic tracheobronchial uptake on PET/CT was recorded. To further evaluate tracheal prostate-specific membrane antigen (PSMA) expression, immunohistochemistry was performed on tracheal samples taken from 2 men who had surgical resection of lung cancer. Tracheal uptake was present in 31 of 100 patients (31%). When tracheal uptake was present, the SUV was significantly higher in the left main bronchus (mean, 2.7) than in the right (mean, 2.3) ( < 0.001). Histopathologic testing of tracheobronchial samples showed PSMA expression in bronchial submucosal glands. In PCa patients undergoing F-DCFPyL PET/CT, tracheobronchial uptake occurred in 31% of patients. This is attributed to normal physiologic PSMA expression in bronchial submucosal glands.
我们评估了在进行前列腺癌（PCa）F-DCFPyL PET/CT 检查的患者中，气管支气管摄取的发生率和潜在病因。该研究纳入了 100 例连续的 PCa 患者，他们均因 F-DCFPyL PET/CT 检查而就诊。回顾性审查了 PET/CT 扫描。记录了 PET/CT 上是否存在生理性气管支气管摄取。为了进一步评估气管前列腺特异性膜抗原（PSMA）的表达，对 2 例接受肺癌手术切除的男性的气管样本进行了免疫组织化学检查。在 100 例患者中有 31 例（31%）存在气管摄取。当存在气管摄取时，左主支气管（平均 SUV 为 2.7）的 SUV 明显高于右主支气管（平均 SUV 为 2.3）（<0.001）。气管支气管样本的组织病理学检测显示支气管黏膜下腺体有 PSMA 表达。在接受 F-DCFPyL PET/CT 检查的 PCa 患者中，31%的患者出现气管支气管摄取。这归因于支气管黏膜下腺体中正常的生理性 PSMA 表达。
