Maternal Fetal Unit, Obstetrics Department, Centro Materno Infantil do Norte, Centro Hospitalar Universitário do Porto, Oporto, Portugal; Instituto Ciências Biomédicas Abel Salazar, Oporto University, Oporto, Portugal; Clinical Immunology Unit, Centro Hospitalar Universitário do Porto, Oporto, Portugal.
Instituto Ciências Biomédicas Abel Salazar, Oporto University, Oporto, Portugal; Clinical Immunology Unit, Centro Hospitalar Universitário do Porto, Oporto, Portugal; Immunology Department, Centro Hospitalar Universitário do Porto, Oporto, Portugal.
J Reprod Immunol. 2023 Sep;159:104122. doi: 10.1016/j.jri.2023.104122. Epub 2023 Jul 22.
During pregnancy, the maternal immune system is challenged to tolerate a semi-allogenic fetus. A proinflammatory profile has been linked to adverse pregnancy outcomes and poor placental development. In this study, the authors evaluated the number of circulating Tregs and Th17 cells in a group of patients diagnosed with preeclampsia(PE) and fetal growth restriction(FGR).
Prospective longitudinal observational study where peripheral blood lymphocyte subsets were analyzed in a cohort of pregnant patients with PE, FGR, and a control group of healthy pregnant women.
The diagnosis of PE was associated with a significative higher number of circulating Th17 cells and a significative relative reduction in the Treg cell count. This proinflammatory profile was also expressed in the evolution of the Th17/ CD4CD25FOXP3 Treg ratio. In the FGR group, the Th17 cell count was significantly higher during the third trimester of pregnancy. This proinflammatory profile was also expressed in the evolution of the Th17/ CD4CD25FOXP3 Treg ratio. When we compare the immunological profiles of patients with PE and FGR we observed a higher number of proinflammatory Th17 cells and a significative lower number of Treg cells in PE patients. This is particularly expressed in the differences found between the Th17/ CD4CD25FOXP3 Treg ratios of these two groups. Discussion/Conclusion Our data showed a that a proinflammatory profile and a relative excess of Th17 cells was associated with the diagnosis of PE and FGR. A more exuberant systemic proinflammatory profile present in the PE patients is absent in patients with FGR without preeclampsia.
在妊娠期间，母体免疫系统受到挑战，需要耐受半同种异体胎儿。促炎表型与不良妊娠结局和胎盘发育不良有关。在这项研究中，作者评估了一组诊断为子痫前期（PE）和胎儿生长受限（FGR）的患者中循环 Treg 和 Th17 细胞的数量。
前瞻性纵向观察性研究，分析了一组患有 PE、FGR 和健康孕妇对照组的孕妇外周血淋巴细胞亚群。
PE 的诊断与循环 Th17 细胞数量显著增加和 Treg 细胞计数相对减少相关。这种促炎表型也表现在 Th17/CD4CD25FOXP3 Treg 比值的演变中。在 FGR 组中，妊娠晚期 Th17 细胞计数明显升高。这种促炎表型也表现在 Th17/CD4CD25FOXP3 Treg 比值的演变中。当我们比较 PE 和 FGR 患者的免疫谱时，我们观察到 PE 患者中促炎 Th17 细胞数量增加，Treg 细胞数量显著减少。这在这两组之间发现的 Th17/CD4CD25FOXP3 Treg 比值差异中表现得尤为明显。讨论/结论：我们的数据表明，促炎表型和 Th17 细胞的相对过剩与 PE 和 FGR 的诊断相关。在没有子痫前期的 FGR 患者中，PE 患者中存在的更为旺盛的全身促炎表型不存在。
