Department of Dermatology, Second Xiangya Hospital of Central South University, Changsha, China.
Clinical Nursing Teaching and Research Section, Second Xiangya Hospital, Central South University, Changsha 410011, China; Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Biomed Pharmacother. 2023 Oct;166:115282. doi: 10.1016/j.biopha.2023.115282. Epub 2023 Aug 9.
Systemic sclerosis (SSc) is an autoimmune disease characterized by immune dysfunction, vascular system dysfunction, and tissue fibrosis. Vascular injury, vascular remodeling, and endothelial dysfunction are the hallmark pathological changes of the disease. In the early stages of SSc development, endothelial cell injury and apoptosis can lead to vascular and perivascular inflammation, oxidative stress, and tissue hypoxia, which can cause clinical manifestations in various organs from the skin to the parenchymal organs. Early diagnosis and rational treatment can improve patient survival and quality of life. Ancillary examinations such as nailfold capillaroscopy as well as optical coherence tomography can help early detect vascular injury in SSc patients. Studies targeting the mechanisms of vascular lesions will provide new perspectives for treatment of SSc.
系统性硬化症（SSc）是一种自身免疫性疾病，其特征为免疫功能紊乱、血管系统功能障碍和组织纤维化。血管损伤、血管重塑和内皮功能障碍是该疾病的标志性病理变化。在 SSc 发展的早期阶段，内皮细胞损伤和凋亡可导致血管和血管周围炎症、氧化应激和组织缺氧，从而导致从皮肤到实质器官的各种器官出现临床表现。早期诊断和合理治疗可以改善患者的生存和生活质量。甲襞毛细血管显微镜检查和光学相干断层扫描等辅助检查有助于早期发现 SSc 患者的血管损伤。针对血管病变机制的研究将为 SSc 的治疗提供新视角。
