Johnson D H, Greco F A
Cancer. 1986 Nov 15;58(10):2198-202. doi: 10.1002/1097-0142(19861115)58:10<2198::aid-cncr2820581006>3.0.co;2-a.
Two patients with metastatic adrenal cortical carcinoma were treated with cisplatin and etoposide. Both achieved a partial remission after only one cycle. One patient had a "nonfunctioning" tumor that had previously regressed on mitotane whereas the second patient presented with classical Cushing's syndrome. Although the latter patient's urinary 17-ketosteroids normalized while receiving mitotane, the tumor itself failed to regress objectively. Cisplatin plus etoposide appears to be an active combination for the treatment of metastatic adrenal cortical carcinoma.
两名转移性肾上腺皮质癌患者接受了顺铂和依托泊苷治疗。仅一个周期后两人均实现部分缓解。一名患者患有“无功能”肿瘤，此前米托坦治疗使其消退，而另一名患者表现为典型的库欣综合征。尽管后一名患者在接受米托坦治疗时尿17-酮类固醇恢复正常，但肿瘤本身并未客观消退。顺铂加依托泊苷似乎是治疗转移性肾上腺皮质癌的有效联合方案。
