Yanagita T, Komiyama S, Kuwano M
Cancer. 1986 Nov 15;58(10):2251-5. doi: 10.1002/1097-0142(19861115)58:10<2251::aid-cncr2820581015>3.0.co;2-y.
The levels of cellular retinol-binding protein (CRBP) were examined by Scatchard analysis in 17 surgically resected human head and neck tumors and their adjacent normal tissues (normal tissues corresponded to muscle tissue). The center area and the marginal area of tumors were tested for their levels of CRBP in 17 cases, and the adjacent tissue was tested in 13 of the 17 cases. Only a small difference (if any) in the dissociation constant (Kd values) was seen in some cases between tumor and adjacent tissue; in most cases the Kd values in both areas were similar, and these values were also similar between the central and marginal areas of tumors. The average level of CRBP in the marginal area of the tumors was higher than that in the center area of the tumors in all the 17 cases. Among the 13 tumor cases whose adjacent tissues were tested, 12 showed CRBP levels more than two times higher in the marginal area of tumors; whereas in only one case was the level in the marginal or the center area of tumor similar to that in the adjacent tissues.
通过Scatchard分析检测了17例手术切除的人头颈部肿瘤及其相邻正常组织（正常组织对应肌肉组织）中的细胞视黄醇结合蛋白（CRBP）水平。对17例肿瘤的中心区域和边缘区域进行了CRBP水平检测，17例中的13例对相邻组织也进行了检测。在肿瘤与相邻组织之间，某些情况下解离常数（Kd值）仅存在微小差异（若有差异）；在大多数情况下，两个区域的Kd值相似，肿瘤的中心区域和边缘区域之间的这些值也相似。在所有17例中，肿瘤边缘区域的CRBP平均水平高于肿瘤中心区域。在检测了相邻组织的13例肿瘤病例中，12例显示肿瘤边缘区域的CRBP水平比相邻组织高出两倍以上；而只有1例肿瘤边缘或中心区域的水平与相邻组织相似。
