Cesk Slov Oftalmol. 2023 Spring;79(4):180-184. doi: 10.31348/2023/23.
The primary aim of the study was to assess the response of intraocular pressure (IOP) to the acute ingestion of hydrogen-rich water (HRW) compared to hydrogen-free water (placebo) in healthy subjects. The effect of HRW intake on central corneal thickness (CCT) was also monitored.
Twenty-four healthy volunteers (5 men, 19 women) aged between 20 and 33 were included in the study, in which one eye of each subject was measured. The study was prospective, randomized and double-blind, with crossover design. Each subject underwent two parts of the experiment, each part on a different day and in random order. In each part of experiment, a total volume of 1260 ml of HRW or placebo was administered over 15 minutes in three doses. IOP and CCT were measured before and during the course of 75 minutes from the start of the HRW or placebo intake.
Administration of both HRW and the placebo caused a significant increase in IOP. The maximum IOP increase was 2.7 mmHg ±2.0 mmHg in minute 25 after the commencement of the experiment (HRW intake), and 1.4 mmHg ±2.0 mmHg in minute 35 (placebo intake). The values of IOP did not differ significantly between both parts, but there were significantly more clinically significant individual IOP increases after HRW intake (58%) compared to the placebo (25%). CCT did not change significantly during the experiment.
The rapid intake of 1260 ml of both HRW and hydrogen-free water causes a statistically significant increase in IOP compared to the baseline in healthy individuals. In the case of HRW, the increase was also clinically significant in most of the subjects. Thus, the results indicate that acute intake of HRW may pose a higher risk than placebo intake in terms of IOP. However, in the case of risk groups such as subjects with glaucoma, ocular hypertension or suspected glaucoma, it is necessary to verify this conclusion by further studies.
本研究的主要目的是评估健康受试者急性摄入富氢水（HRW）与不含氢水（安慰剂）对眼压（IOP）的反应。还监测了 HRW 摄入对中央角膜厚度（CCT）的影响。
本研究纳入了 24 名年龄在 20 至 33 岁之间的健康志愿者（5 名男性，19 名女性），每只眼均进行了测量。该研究为前瞻性、随机、双盲、交叉设计。每位受试者进行了两部分实验，每部分均在不同的日子进行，且顺序随机。在实验的每一部分中，受试者在 15 分钟内分三次共摄入 1260 毫升 HRW 或安慰剂。在 HRW 或安慰剂摄入开始后 75 分钟内，测量 IOP 和 CCT。
HRW 和安慰剂的给药均导致 IOP 显著升高。实验开始后第 25 分钟时，最大 IOP 升高 2.7mmHg±2.0mmHg（HRW 摄入），第 35 分钟时升高 1.4mmHg±2.0mmHg（安慰剂摄入）。两部分之间的 IOP 值无显著差异，但 HRW 摄入后有更多的临床显著个体 IOP 升高（58%），而安慰剂摄入后仅有 25%。实验过程中 CCT 无显著变化。
快速摄入 1260 毫升 HRW 和不含氢水均可导致健康个体的 IOP 与基线相比呈统计学显著升高。在 HRW 的情况下，大多数受试者的升高也具有临床意义。因此，结果表明与安慰剂摄入相比，急性摄入 HRW 可能会导致更高的 IOP 风险。但是，对于青光眼、高眼压或疑似青光眼等风险群体，需要通过进一步研究来验证这一结论。
