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经皮椎旁肌平面阻滞在单节段与双节段切口术前镇痛效果的比较:一项前瞻性、随机、双盲试验。

Comparison of the effects of one-level and bi-level pre-incisional erector spinae plane block on postoperative acute pain in video-assisted thoracoscopic surgery; a prospective, randomized, double-blind trial.

机构信息

Ankara Bilkent City Hospital, Anesthesiology and Reanimation Clinic, Ministry of Health, Ankara, Turkey.

Ankara Etlik City Hospital, Anesthesiology and Reanimation Clinic, Ministry of Health, Ankara, Turkey.

出版信息

BMC Anesthesiol. 2023 Aug 11;23(1):270. doi: 10.1186/s12871-023-02232-8.

Abstract

BACKGROUND

This prospective, randomized, double-blind trial aimed to compare the postoperative analgesic efficacy of One-Level pre-incisional erector spinae plane block (ESPB) and Bi-Level pre-incisional ESPB in patients undergoing video-assisted thoracic surgery (VATS).

METHODS

This pilot trial was conducted between April 2022 and February 2023 with sixty patients. The patients were randomly divided into two groups. In One-Level ESPB Group (n = 30) block was performed at the thoracal(T)5 level with the 30 ml 0.25% bupivacaine. In the Bi-Level ESPB Group (n = 30) block was performed at T4 and T6 levels by using 15 ml of 0.25% bupivacaine for each level. In the postoperative period, 50 mg dexketoprofen every 12 h and 1 g paracetamol every 8 h were given intravenously (IV). Patient-controlled analgesia (PCA) prepared with morphine was applied to the patients. 0.5 mg/kg of tramadol was administered via IV for rescue analgesia. Visual analog scale (VAS) scores were recorded in the postoperative 1, 2, 4, 12, 24, and 48 -hours. The need for additional analgesics and side effects were recorded. In two groups, patients' demographics and postoperative hemodynamic data were recorded.

RESULTS

VAS scores at resting were statistically significantly higher at the 1 (p: 0.002) and 4 -hour (p: 0.001) in the One-Level ESPB. When the groups were evaluated in terms of VAS coughing scores, the 4 -hour (p: 0.001) VAS coughing scores results were found to be statistically significantly higher in the One-Level ESPB group. In terms of VAS values evaluated during follow-up, the rates of VAS coughing score > 3 values were found to be statistically significantly lower in the Bi-Level ESPB group (p: 0.011). There was no statistically significant difference between the groups in terms of side effects, morphine consumption, and additional analgesic use (p > 0.05).

CONCLUSIONS

Adequate analgesia was achieved in the early postoperative period in the group treated with Bi-Level ESPB with similar morphine consumption and side effects. This may be an advantage, especially in the early postoperative period when the pain is quite intense.

摘要

背景

本前瞻性、随机、双盲试验旨在比较单水平切口前竖脊肌平面阻滞(ESPB)和双水平切口前 ESPB 在接受电视辅助胸腔镜手术(VATS)的患者中的术后镇痛效果。

方法

本试验于 2022 年 4 月至 2023 年 2 月进行,共纳入 60 例患者。患者随机分为两组。在单水平 ESPB 组(n=30)中,在 T5 水平进行阻滞,用 30ml0.25%布比卡因。在双水平 ESPB 组(n=30)中,在 T4 和 T6 水平进行阻滞,每个水平用 15ml0.25%布比卡因。在术后期间,静脉给予 50mg 右旋酮洛芬每 12 小时一次和 1g 对乙酰氨基酚每 8 小时一次。患者接受吗啡制备的自控镇痛(PCA)。静脉给予 0.5mg/kg 曲马多进行解救镇痛。记录术后 1、2、4、12、24 和 48 小时的视觉模拟评分(VAS)。记录额外镇痛需求和不良反应。在两组中,记录患者的人口统计学和术后血流动力学数据。

结果

在单水平 ESPB 组,静息时的 VAS 评分在 1 小时(p:0.002)和 4 小时(p:0.001)时明显更高。当按 VAS 咳嗽评分评估两组时,在单水平 ESPB 组,4 小时(p:0.001)VAS 咳嗽评分结果明显更高。在随访期间评估的 VAS 值方面,在 Bi-Level ESPB 组,VAS 咳嗽评分值>3 的发生率明显更低(p:0.011)。在不良反应、吗啡用量和额外镇痛使用方面,两组间无统计学差异(p>0.05)。

结论

Bi-Level ESPB 组在术后早期获得了足够的镇痛效果,吗啡用量和不良反应相似。这可能是一个优势,特别是在疼痛相当剧烈的术后早期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f4a/10416471/adebfddf6f89/12871_2023_2232_Fig1_HTML.jpg

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