与乳房切除术相比，保乳治疗降低了乳腺癌患者的心脏特异性死亡率。

Breast conservation therapy decreased heart-specific mortality in breast cancer patients compared with mastectomy.

机构信息

Department of Thyroid and Breast Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.

出版信息

BMC Surg. 2023 Aug 12;23(1):233. doi: 10.1186/s12893-023-02132-1.

DOI:10.1186/s12893-023-02132-1

PMID:37568124

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10422722/

Abstract

AIM

To investigate the impacts of breast conservation therapy (BCT) and mastectomy on heart-specific mortality in breast cancer patients.

METHODS

Patients with primary breast cancer registered in the Surveillance, Epidemiology, and End Results (SEER) database between Jan 1998 and Dec 2015 were included. Patients were divided into either breast conservation therapy or mastectomy group. To compare mortality caused by heart diseases in breast cancer patients with BCT or mastectomy, univariate and multivariate regression after propensity score matching (PSM) were performed. Kaplan-Meier analysis was also used to evaluate heart-specific survival between two groups.

RESULTS

132,616 patients with breast cancer were enrolled in this study. After PSM, four risk factors including age, race, marital status and types of surgery were identified significantly associated with death from heart diseases. Heart-specific survival analysis further showed that overall, BCT poses a lower risk to heart-specific mortality compared with mastectomy.

CONCLUSION

Compared with mastectomy, BCT significantly decreased heart-specific mortality in breast cancer patients.

摘要

目的

探讨保乳治疗（BCT）和乳房切除术对乳腺癌患者心脏特异性死亡率的影响。

方法

纳入 1998 年 1 月至 2015 年 12 月期间登记在监测、流行病学和最终结果（SEER）数据库中的原发性乳腺癌患者。患者分为保乳治疗或乳房切除术组。为了比较 BCT 或乳房切除术治疗的乳腺癌患者因心脏病导致的死亡率，在进行倾向评分匹配（PSM）后进行单变量和多变量回归。还使用 Kaplan-Meier 分析评估两组之间的心脏特异性生存率。