Uematsu M, Kondo M
Cancer. 1986 Nov 1;58(9):1979-84. doi: 10.1002/1097-0142(19861101)58:9<1979::aid-cncr2820580904>3.0.co;2-0.
Eleven patients with invasive thymoma were treated with radiotherapy. All patients had gross anterior mediastinal tumors that invaded the adjacent structures, four of whom showed intrathoracic dissemination. Before radiotherapy, only one had macroscopic complete resection of the tumor, and another had partial resection; the other nine patients underwent biopsy only. All 11 patients achieved complete remission after radiotherapy, eight of whom have been free from relapse for 31 to 202 months. Three patients experienced recurrence within the thorax but outside the radiation fields. Even after whole mediastinal irradiation, recurrence could occur in the pleural cavity. Therefore, extended radiation fields including the entire hemithorax is recommended. Intensive combination chemotherapy was administered for two patients with recurrence and they achieved complete remission. A possible role of intensive chemotherapy in induction phase for invasive thymomas is discussed.
11例侵袭性胸腺瘤患者接受了放射治疗。所有患者均有侵犯相邻结构的前纵隔巨大肿瘤，其中4例有胸内播散。放疗前，仅1例患者肿瘤获得肉眼完全切除，另1例为部分切除；其余9例患者仅接受了活检。所有11例患者放疗后均达到完全缓解，其中8例已无复发31至202个月。3例患者在胸腔内但在放射野外复发。即使进行了全纵隔照射，胸腔内仍可能复发。因此，建议扩大放射野，包括整个半侧胸腔。对2例复发患者给予了强化联合化疗，他们均达到了完全缓解。文中讨论了强化化疗在侵袭性胸腺瘤诱导期可能发挥的作用。
