Ichinose Y, Ohta M, Yano T, Yokoyama H, Asoh H, Hata K
Department of Chest Surgery, National Kyushu Cancer Center, Fukuoka, Japan.
J Surg Oncol. 1993 Nov;54(3):180-3. doi: 10.1002/jso.2930540311.
The outcome of eight patients with invasive thymoma accompanying pleural dissemination was investigated. Only two patients had mediastinal tumor resection and pleural disseminated tumor excision. Seven patients underwent radiotherapy to the mediastinum and/or disseminated tumors. A clinical response to radiotherapy was achieved in the six patients with evaluable lesions (complete response in five patients and partial response in one). The estimated 5-year survival rate was 87.5%. Four patients were alive more than 10 years. So far, the mediastinal tumors of seven patients have been controlled for periods ranging from 42 to 154 months. Recurrence in six patients appeared as pleural tumors. Four out of the six patients had five courses of radiotherapy to the recurrent pleural tumors, four of which achieved complete response. No distant metastases were observed at any time. These observations suggest that radiotherapy should be the primary mode of treatment in cases of invasive thymoma with pleural dissemination.
对8例伴有胸膜播散的侵袭性胸腺瘤患者的治疗结果进行了调查。仅2例患者接受了纵隔肿瘤切除术和胸膜播散性肿瘤切除术。7例患者接受了纵隔和/或播散性肿瘤的放射治疗。6例有可评估病变的患者对放射治疗有临床反应（5例完全缓解，1例部分缓解）。估计5年生存率为87.5%。4例患者存活超过10年。到目前为止，7例患者的纵隔肿瘤已得到控制，时间为42至154个月。6例患者复发表现为胸膜肿瘤。6例患者中有4例对复发性胸膜肿瘤进行了5个疗程的放射治疗，其中4例达到完全缓解。在任何时候均未观察到远处转移。这些观察结果表明，放射治疗应是伴有胸膜播散的侵袭性胸腺瘤病例的主要治疗方式。
