Schwartz D, Banner B F, Roseman D L, Coon J S
Cancer. 1986 Nov 1;58(9):2082-8. doi: 10.1002/1097-0142(19861101)58:9<2082::aid-cncr2820580920>3.0.co;2-j.
Multiple, synchronous, apparently primary carcinomas of the colon are a relatively common occurrence. The DNA ploidy in 23 colon carcinomas from 10 patients was determined to see if this parameter supported common or independent origins for such synchronous lesions. Paraffin blocks of each tumor were prepared for flow cytometry, then analyzed for nuclear DNA content. In 3 of the 10 cases, the tumors within each colon differed with respect to DNA ploidy; in four cases all tumors were diploid; and in three cases both (all) tumors within each colon had identical aneuploid DNA indices. Tumors from the same colon with identical DNA histograms often had dissimilar histology. The replicate aneuploid DNA indices strongly suggest a common origin for the multiple tumors within these colons; tumors in the other groups are compatible with either single or multiple origins. These findings suggest that multiple "primary" colon carcinomas may, in some cases, arise as translumenal metastases from an initial single lesion.
多发、同步出现的原发性结肠癌较为常见。对10例患者的23个结肠癌进行DNA倍体分析，以确定该参数是否支持这些同步病变的共同起源或独立起源。为流式细胞术准备每个肿瘤的石蜡块，然后分析核DNA含量。在10例中的3例中，每个结肠内的肿瘤在DNA倍体方面存在差异；4例中所有肿瘤均为二倍体；3例中每个结肠内的两个（所有）肿瘤具有相同的非整倍体DNA指数。来自同一结肠且具有相同DNA直方图的肿瘤通常具有不同的组织学。重复的非整倍体DNA指数强烈提示这些结肠内多个肿瘤的共同起源；其他组中的肿瘤与单一或多个起源均相符。这些发现表明，在某些情况下，多个“原发性”结肠癌可能是由最初的单个病变经腔转移而来。
