Parisi Simona, Gambardella Claudio, Conzo Giovanni, Ruggiero Roberto, Tolone Salvatore, Lucido Francesco Saverio, Iovino Francesco, Fisone Francesca, Brusciano Luigi, Parmeggiani Domenico, Docimo Ludovico
Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Department of Advanced Medical and Surgical Sciences, School of Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
J Clin Med. 2023 Aug 2;12(15):5076. doi: 10.3390/jcm12155076.
Breast conservative surgery is the primary therapeutic choice for non-aggressive early breast cancers, and a minimally-invasive approach is strongly recommended. The breast localization represents a modern challenge for surgery. Wire-guided localization is still the gold standard technique, but new wireless systems have been proposed, such as radiofrequency identification with LOCalizer (Hologic, Santa Carla, CA, USA), which reports encouraging results. The current study aimed to evaluate the accuracy and efficacy of the combined use of LOCalizer and ultrasound compared with the results obtained using LOCalizer alone for the detection of non-palpable breast cancer. Ninety-six patients who were candidates for breast localization were enrolled. Group A received a combined localization with LOCalizer and US, while group B underwent only LOCalizer identification. Oncological radicality was reached in 100% of the patients in Group A and in 89.2% of the patients in Group B, with = 0.006. The mean specimens' volume was 13.2 ± 0.6 cm for Group A and 16.1 ± 1.4 cm for Group B, while mean specimen weights were 21.8 ± 2.2 and 24.4 ± 1.8 g, respectively ( = 0.003 and = 0.004, respectively). LOCalizer with ultrasound, in the current series, has resulted in the preferred option for the localization of non-palpable breast cancer, allowing limited resection (in weight and volume), guaranteeing excellent oncological outcomes, and great satisfaction for patients and physicians.
保乳手术是侵袭性不强的早期乳腺癌的主要治疗选择，强烈推荐采用微创方法。乳腺定位对手术来说是一项现代挑战。金属丝引导定位仍是金标准技术，但已提出了新的无线系统，如使用定位器（美国加利福尼亚州圣克拉拉市的Hologic公司生产）的射频识别技术，其报告的结果令人鼓舞。本研究旨在评估与单独使用定位器相比，联合使用定位器和超声在检测不可触及乳腺癌方面的准确性和有效性。招募了96名适合乳腺定位的患者。A组接受定位器和超声联合定位，而B组仅进行定位器识别。A组100%的患者和B组89.2%的患者达到了肿瘤根治性，P = 0.006。A组标本的平均体积为13.2±0.6立方厘米，B组为16.1±1.4立方厘米，而平均标本重量分别为21.8±2.2克和24.4±1.8克（分别为P = 0.003和P = 0.004）。在本系列研究中，超声联合定位器已成为不可触及乳腺癌定位的首选方法，可实现有限切除（重量和体积方面），保证出色的肿瘤学结果，并让患者和医生都非常满意。
