Shin Hee Jong, Oh Si Eun, Park Chan Kee, Park Hae-Young Lopilly
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
J Clin Med. 2023 Aug 2;12(15):5091. doi: 10.3390/jcm12155091.
To explore various parameters that can evaluate the central visual impairment in patients with early-stage glaucoma, we included patients into a study with central visual impairments with an MD value greater than -6.0 dB on the 24-2 VF test. A possible association between structural parameters acquired by OCT and functional parameters of VF and PERG was determined. A total of 70 eyes of patients with suspected glaucoma or NTG underwent VF, OCT, and PERG examinations. The patients were classified into two groups according to the MD of the 24-2 VF test. We used Pearson correlation analysis to evaluate the relationships between GCIPL thickness/RNFL thickness and visual functional parameters, such as PERG and perimetry. Linear regression analyses were conducted to evaluate the significant factors affecting the PSD of VF 10-2. In the low MD group, the P50 amplitude presented significant correlations (r = 0.346, = 0.048) with GCIPL thickness. In the correlation analysis of the high MD group, it was found that only the PSD of 10-2 uniquely presented borderline significant correlations with GCIPL thickness (r = -0.327, = 0.055), and no other functional parameter showed significant correlation. Univariate and multivariate analyses revealed that GCIPL thickness was significantly associated with a PSD of 10-2 VF ( < 0.001 and 0.013, respectively). Among various parameters, the P50 amplitude and 10-2 PSD demonstrated statistically borderline significant structure-function relationships with GCIPL thickness in early-stage glaucoma.
为了探索可评估早期青光眼患者中心视力损害的各种参数，我们将24-2视野测试中平均缺损（MD）值大于-6.0 dB的中心视力损害患者纳入一项研究。确定了光学相干断层扫描（OCT）获取的结构参数与视野（VF）和图形视网膜电图（PERG）功能参数之间的可能关联。共有70例疑似青光眼或正常眼压性青光眼患者的眼睛接受了VF、OCT和PERG检查。根据24-2视野测试的MD将患者分为两组。我们使用Pearson相关分析来评估青光眼性黄斑内层神经纤维层（GCIPL）厚度/视网膜神经纤维层（RNFL）厚度与视觉功能参数（如PERG和视野检查）之间的关系。进行线性回归分析以评估影响10-2视野模式标准差（PSD）的重要因素。在低MD组中，P50波幅与GCIPL厚度呈现显著相关性（r = 0.346，P = 0.048）。在高MD组的相关分析中，发现仅10-2的PSD与GCIPL厚度呈现边缘显著相关性（r = -0.327，P = 0.055），而没有其他功能参数显示出显著相关性。单因素和多因素分析显示，GCIPL厚度与10-2视野的PSD显著相关（分别为P < 0.001和0.013）。在各种参数中，P50波幅和10-2 PSD在早期青光眼中与GCIPL厚度表现出统计学上的边缘显著结构-功能关系。
