Vu Trung, Fowler Annaliese, McCarty Nami
Center for Stem Cell and Regenerative Disease, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), The University of Texas-Health Science Center at Houston, Houston, TX 77030, USA.
The Department of Biomedical Engineering at Texas A&M University, Houston, TX 77030, USA.
Cancers (Basel). 2023 Jul 26;15(15):3792. doi: 10.3390/cancers15153792.
The p53 protein is an important tumor suppressor, and TP53 mutations are frequently associated with poor prognosis in various cancers. Mutations in TP53 result in a loss of p53 function and enhanced expression of cell cycle genes, contributing to the development and progression of cancer. Meanwhile, several tripartite motif (TRIM) proteins are known to regulate cell growth and cell cycle transition. However, the prognostic values between TP53 and TRIM family genes in cancer are unknown. In this study, we analyzed the relationship between the mutations and TRIM family proteins and evaluated the prognostic significance of TRIM family proteins in cancer patients with P53 mutations. Our findings identified specific TRIM family members that are upregulated in mutant tumors and are associated with the activation of genes related to a cell-cycle progression in the context of TP53 mutations.
p53蛋白是一种重要的肿瘤抑制因子，TP53突变在多种癌症中常与预后不良相关。TP53突变导致p53功能丧失和细胞周期基因表达增强，促进癌症的发生和发展。同时，已知几种三联基序（TRIM）蛋白可调节细胞生长和细胞周期转换。然而，TP53与TRIM家族基因在癌症中的预后价值尚不清楚。在本研究中，我们分析了TP53突变与TRIM家族蛋白之间的关系，并评估了TRIM家族蛋白在P53突变癌症患者中的预后意义。我们的研究结果确定了在突变肿瘤中上调的特定TRIM家族成员，这些成员在TP53突变的情况下与细胞周期进程相关基因的激活有关。
