Farber Nicole I, Li Yimin, Solis Roberto N, Chen Joy, Masheeb Zahrah, Wilson Machelle, Bewley Arnaud F, Abouyared Marianne, Rao Shyam, Rong Yi, Birkeland Andrew C
Department of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USA.
Department of Radiation Oncology, University of California Davis, Sacramento, CA 94720, USA.
Cancers (Basel). 2023 Jul 29;15(15):3865. doi: 10.3390/cancers15153865.
Though specific growth rate (SGR) has potential prognostic value for oropharyngeal squamous cell carcinoma (OPSCC), there is sparse literature defining these rates. Our aims were to establish the SGRs of primary tumors (PTs) and lymph nodes (LNs) in OPSCC and to correlate SGR with oncologic outcome. A pilot study was designed with a retrospective analysis examining 54 patients from the University of California, Davis with OPSCC (diagnosed 2012-2019). Radiation oncology software and pretreatment serial CT scans were used to measure PT and LN volumes to calculate SGR and doubling time (DT). The mean PT-SGR was 1.2 ± 2.2%/day and the mean LN-SGR was 1.6 ± 1.9%/day. There was no statistically significant difference between slow-growing and fast-growing cohorts in terms of age, gender, smoking status, tumor subsite, HPV status (as determined with p16 staining), initial volume, or overall stage. SGR had no impact on 2-year overall survival, disease-free survival, or disease-specific survival. We found the average daily growth rates for OPSCC to be 1.2%/day and 1.6%/day. Our findings suggest PT- and LN-SGR are independent factors, not heavily influenced by known biomarkers and patient characteristics, without a statistical impact on prognosis. This information has value in patient counseling regarding tumor growth and in providing patients worried about fast-growing tumors the appropriate reassurance.
尽管特定生长率（SGR）对口咽鳞状细胞癌（OPSCC）具有潜在的预后价值，但定义这些生长率的文献却很少。我们的目的是确定OPSCC中原发性肿瘤（PTs）和淋巴结（LNs）的SGR，并将SGR与肿瘤学结果相关联。我们设计了一项试点研究，通过回顾性分析对来自加利福尼亚大学戴维斯分校的54例OPSCC患者（2012 - 2019年确诊）进行研究。利用放射肿瘤学软件和治疗前的系列CT扫描来测量PT和LN的体积，以计算SGR和倍增时间（DT）。PT的平均SGR为1.2±2.2%/天，LN的平均SGR为1.6±1.9%/天。在年龄、性别、吸烟状况、肿瘤亚部位、HPV状态（通过p16染色确定）、初始体积或总体分期方面，生长缓慢和生长快速的队列之间没有统计学上的显著差异。SGR对2年总生存率、无病生存率或疾病特异性生存率没有影响。我们发现OPSCC的平均每日生长率分别为1.2%/天和1.6%/天。我们的研究结果表明，PT-SGR和LN-SGR是独立因素，不受已知生物标志物和患者特征的严重影响，对预后没有统计学影响。这些信息在为患者提供有关肿瘤生长的咨询以及为担心肿瘤生长迅速的患者提供适当的安慰方面具有价值。
