Fojnica Adnan, Gromilic Zehra, Vranic Semir, Murkovic Michael
Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, 8036 Graz, Austria.
Institute of Biochemistry, Graz University of Technology, 8010 Graz, Austria.
Cancers (Basel). 2023 Jul 30;15(15):3874. doi: 10.3390/cancers15153874.
Novel therapeutic agents to combat cancer is an active area of research, as current treatment options have limitations in efficacy and tolerability. One of these therapeutic agents in our immediate environment is cyclolinopeptides (CLPs). CLPs have several advantages that make them suitable for daily consumption and potential therapeutics in cancer research. They are natural compounds, having high specificity, low toxicity, low cost, and an overall simple extraction process. Over the years, numerous in vitro studies in cancer cells demonstrated CLPs to possess anti-proliferative, apoptotic, and anti-angiogenic effects, as well as the ability to induce cell cycle arrest and inhibit cancer cell growth in various cancer types, including breast cancer, gastric cancer, and melanoma. This paper provides an overview of the significance and potential of CLPs as therapeutic agents, emphasizing their promising role in cancer treatment based on different cancer cell lines. The mechanism of action of CLPs in cancer cells is multifaceted. It involves the modulation of multiple signaling pathways, including inhibition of protein kinases, modulation of apoptosis-related proteins, and regulation of oxidative stress and inflammation.
新型抗癌治疗药物是一个活跃的研究领域，因为目前的治疗选择在疗效和耐受性方面存在局限性。在我们身边的这些治疗药物之一是环脂肽（CLPs）。环脂肽有几个优点，使其适合日常使用，并在癌症研究中具有潜在的治疗价值。它们是天然化合物，具有高特异性、低毒性、低成本以及整体简单的提取过程。多年来，在癌细胞中进行的大量体外研究表明，环脂肽具有抗增殖、凋亡和抗血管生成作用，以及在包括乳腺癌、胃癌和黑色素瘤在内的各种癌症类型中诱导细胞周期停滞和抑制癌细胞生长的能力。本文概述了环脂肽作为治疗药物的意义和潜力，强调了它们在基于不同癌细胞系的癌症治疗中的前景。环脂肽在癌细胞中的作用机制是多方面的。它涉及多种信号通路的调节，包括抑制蛋白激酶、调节凋亡相关蛋白以及调节氧化应激和炎症。
