Gera Kriti, Martir Daniela, Xue Wei, Wingard John R
Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Department of Biostatistics, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Cancers (Basel). 2023 Aug 3;15(15):3941. doi: 10.3390/cancers15153941.
Acute erythroid leukemia (AEL), also known as pure erythroid leukemia, is a rare subtype of acute myeloid leukemia (AML) characterized by the proliferation of malignant erythroid precursors. Outcome data at the population level are scarce.
We performed a retrospective analysis of the Surveillance Epidemiology and End Results (SEER) database. All cases with a histologically confirmed diagnosis of acute (pure) erythroid leukemia during the period of 2000-2019 were included in the study. The Kaplan-Meier method was used to perform survival analysis. The significance of differences between overall survival (OS) was analyzed using the log-rank test.
In total, 968 patients were included in the study. The median age was 68 years (range 0-95), 62% of patients were males, and 62.5% ( = 605) were treated with chemotherapy. The median OS for <18, 18-49, 50-64, 65-79 and 80+ age groups was 69, 18, 8, 3 and 1 month, respectively ( < 0.0001). Patients who received chemotherapy had significantly improved OS compared to patients who did not, among both adults ( < 0.0001) and children ( = 0.004). There were no significant differences in OS based on sex, race, ethnicity and median household income. Median OS for adults diagnosed in 2000-2004, 2005-2009, 2010-2014, 2015-2019 was 4, 6, 6 and 3 months, respectively, with no significant differences in OS between these groups.
AEL occurs in all age groups but is most common in the elderly. Outcomes are poor with current chemotherapeutic agents, with no improvement in the last two decades. This study stresses the urgent need for investigational agents.
急性红系白血病（AEL），也称为纯红系白血病，是急性髓系白血病（AML）的一种罕见亚型，其特征为恶性红系前体细胞的增殖。人群水平的结局数据稀缺。
我们对监测、流行病学和最终结果（SEER）数据库进行了回顾性分析。纳入了2000年至2019年期间组织学确诊为急性（纯）红系白血病的所有病例。采用Kaplan-Meier方法进行生存分析。使用对数秩检验分析总生存（OS）之间差异的显著性。
本研究共纳入968例患者。中位年龄为68岁（范围0 - 95岁），62%的患者为男性，62.5%（n = 605）接受了化疗。年龄<18岁、18 - 49岁、50 - 64岁、65 - 79岁和80岁及以上年龄组的中位OS分别为69个月、18个月、8个月、3个月和1个月（P < 0.0001）。接受化疗的患者与未接受化疗的患者相比，成人（P < 0.0001）和儿童（P = 0.004）的OS均有显著改善。基于性别、种族、民族和家庭收入中位数的OS无显著差异。2000 - 2004年、2005 - 2009年、2010 - 2014年、2015 - 2019年诊断的成人患者的中位OS分别为4个月、6个月、6个月和3个月，这些组之间的OS无显著差异。
AEL发生于所有年龄组，但在老年人中最为常见。目前的化疗药物治疗效果不佳，近二十年来无改善。本研究强调迫切需要研究性药物。
