Sato Shingo, Kobayashi Masayuki, Suzaki Ken, Nanke Ittoku, Kosugi Nobuharu
Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, Japan.
Department of Hematology, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, Japan.
Hematol Rep. 2022 Mar 19;14(1):38-44. doi: 10.3390/hematolrep14010007.
Pure erythroid leukemia (PEL) is an extremely rare type of acute myeloid leukemia (AML), accounting for fewer than 1% of all AML cases. A 72-year-old man presented with severe fatigue. His bone marrow aspiration contained myeloperoxidase negative abnormal cells that were aggregating and depicting epithelial adhesion, suggesting the possibility of solid tumor metastasis. His general condition deteriorated during medical diagnosis, and he died soon after starting chemotherapy. PEL appeared to be the definitive diagnosis after evaluating the histopathological findings, which were obtained after his death. With atypical morphological features, immunophenotypic and karyotypic approaches must be integrated for PEL assessment.
纯红细胞白血病（PEL）是一种极其罕见的急性髓系白血病（AML），占所有AML病例的比例不到1%。一名72岁男性出现严重疲劳。他的骨髓穿刺检查发现髓过氧化物酶阴性的异常细胞聚集并呈现上皮黏附现象，提示可能为实体瘤转移。在医学诊断过程中他的一般状况恶化，开始化疗后不久便去世。在评估其死后获得的组织病理学结果后，PEL似乎成为明确诊断。由于具有非典型形态特征，必须结合免疫表型和核型分析方法来评估PEL。
