Liu Chia-Chi, Cheng Ya-Fu, Ke Pei-Cing, Chen Yi-Ling, Lin Ching-Min, Wang Bing-Yen
Division of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan.
Surgery Clinical Research Center, Changhua Christian Hospital, Changhua 50006, Taiwan.
Cancers (Basel). 2023 Aug 3;15(15):3952. doi: 10.3390/cancers15153952.
Volume doubling time (VDT) has been proven to be a powerful predictor of lung cancer progression. In non-small cell lung cancer patients receiving sublobar resection, the discussion of correlation between VDT and surgery was absent. We proposed to investigate the surgical outcomes according to VDT.
We retrospectively studied 96 cases post sublobar resection from 2012 to 2018, collecting two chest CT scans preoperatively of each case and calculating the VDT. The receiver operating characteristic curve was constructed to identify the optimal cut-off point of VDTs as 133 days. We divided patients into two groups: VDT < 133 days and VDT ≥ 133 days. Univariable and multivariable analyses were performed for comparative purposes.
Univariable and multivariable analyses revealed that the consolidation and tumor diameter ratio was the factor of overall survival (OS), and VDT was the only factor of disease-free survival (DFS). The five year OS rates of patients with VDTs ≥ 133 days and VDTs < 133 days, respectively, were 89.9% and 71.9%, and the five year DFS rates were 95.9% and 61.5%.
As VDT serves as a powerful prognostic predictor and provides an essential role in planning surgical procedures, the evaluation of VDT preoperatively is highly suggested.
体积倍增时间（VDT）已被证明是肺癌进展的有力预测指标。在接受亚肺叶切除的非小细胞肺癌患者中，尚未讨论VDT与手术之间的相关性。我们建议根据VDT来研究手术结果。
我们回顾性研究了2012年至2018年间96例接受亚肺叶切除的患者，收集了每例患者术前的两次胸部CT扫描图像并计算VDT。构建受试者工作特征曲线以确定VDT的最佳截断点为133天。我们将患者分为两组：VDT<133天和VDT≥133天。为进行比较，进行了单变量和多变量分析。
单变量和多变量分析显示，实变与肿瘤直径比是总生存期（OS）的影响因素，而VDT是无病生存期（DFS）的唯一影响因素。VDT≥133天和VDT<133天的患者五年总生存率分别为89.9%和71.9%，五年无病生存率分别为95.9%和61.5%。
由于VDT是一个有力的预后预测指标，并且在手术方案规划中起着重要作用，因此强烈建议术前评估VDT。
