Moran Cesar A
MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.
Diagnostics (Basel). 2023 Jul 26;13(15):2477. doi: 10.3390/diagnostics13152477.
Primary carcinomas of the lung are vastly represented by the conventional types of adenocarcinomas or squamous cell carcinomas. However, there are other types of non-small cell carcinomas that although uncommon represent a meaningful group that often pose a problem not only in diagnosis but also in classification. Spindle cell and/or giant cell carcinomas, although uncommon represent an important group of primary lung carcinomas. Important to highlight is that current criteria are rather ambiguous and likely not up to date, which renders the classification of these tumors somewhat more obscure. In addition, with the daily use of immunohistochemical stains, the classification of these tumors may also pose a different problem in the proper allocation of these tumors. Proper classification is highly important in the selection process that takes place using such material for molecular analysis. The current molecular characteristics of these tumors are limited and lack more in-depth studies and analyses that can provide specific targets for the treatment of patients with these tumors. The current review attempts to highlight the shortcomings in the current classification and definitions of these neoplasms as well as the more current view regarding these tumors when the use of immunohistochemical stains is employed.
原发性肺癌主要由传统类型的腺癌或鳞状细胞癌构成。然而，还有其他类型的非小细胞癌，尽管不常见，但却是一个有意义的群体，不仅在诊断方面，而且在分类方面常常带来问题。梭形细胞和/或巨细胞癌虽然不常见，但却是原发性肺癌的一个重要群体。需要强调的是，当前的标准相当模糊且可能过时，这使得这些肿瘤的分类更加模糊不清。此外，随着免疫组化染色的日常使用，这些肿瘤的分类在将其正确归类时也可能带来不同的问题。在使用此类材料进行分子分析的选择过程中，正确分类非常重要。这些肿瘤目前的分子特征有限，缺乏能为这些肿瘤患者治疗提供特定靶点的更深入研究和分析。当前的综述试图突出这些肿瘤在当前分类和定义中的不足，以及在使用免疫组化染色时对这些肿瘤的最新观点。
