Hong Kirim, Park Hee Jin, Jang Hee Yeon, Shim Sung Han, Jang Yoon, Kim Soo Hyun, Cha Dong Hyun
CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, CHA University, Seoul 06125, Republic of Korea.
Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.
Diagnostics (Basel). 2023 Jul 30;13(15):2532. doi: 10.3390/diagnostics13152532.
As the prevalence of pregnancies with advanced maternal age increases, the risk of fetal chromosomal abnormalities is on the rise. Therefore, prenatal genetic screening and diagnosis have become essential elements in contemporary obstetrical care. Trophoblast retrieval and isolation from the cervix (TRIC) is a non-invasive procedure that can be utilized for prenatal genetic diagnosis. The method involves the isolation of fetal cells (extravillous trophoblasts) by transcervical sampling; along with its non-invasiveness, TRIC exhibits many other advantages such as its usefulness in early pregnancy at 5 weeks of gestation, and no interference by various fetal and maternal factors. Moreover, the trophoblast yields from TRIC can provide valuable information about obstetrical complications related to abnormal placentation even before clinical symptoms arise. The standardization of this clinical tool is still under investigation, and the upcoming advancements in TRIC are expected to meet the increasing need for a safe and accurate option for prenatal diagnosis.
随着高龄孕产妇妊娠率的上升，胎儿染色体异常的风险也在增加。因此，产前基因筛查和诊断已成为当代产科护理的重要组成部分。经宫颈获取和分离滋养层细胞（TRIC）是一种可用于产前基因诊断的非侵入性方法。该方法通过经宫颈采样分离胎儿细胞（绒毛外滋养层细胞）；除了非侵入性外，TRIC还具有许多其他优点，例如在妊娠5周的早期妊娠中有用，且不受各种胎儿和母体因素的干扰。此外，TRIC获得的滋养层细胞甚至在临床症状出现之前就能提供有关与胎盘异常相关的产科并发症的有价值信息。这种临床工具的标准化仍在研究中，预计TRIC即将取得的进展将满足对安全、准确的产前诊断选项日益增长的需求。
