白藜芦醇负载油基有机凝胶纳米颗粒：一种对抗A375人黑色素瘤细胞的潜在纳米载体。
Resveratrol-Loaded Oil Organogel Nanoparticles: A Potential Nanocarrier against A375 Human Melanoma Cells.
作者信息
Dourado Douglas, Batista Fabiana Pacheco Reis, Philadelpho Biane Oliveira, de Souza Myla Lôbo, de Cerqueira E Silva Mariana Barros, de Grandis Rone Aparecido, Miranda Priscila Anjos, Colauto Nelson Barros, Pereira Daniel T, Formiga Fabio Rocha, Cilli Eduardo Maffud, Pavan Fernando Rogério, Oliveira de Souza Carolina, Ferreira Ederlan de Souza
机构信息
School of Pharmacy, Federal University of Rio Grande do Norte (UFRN), General Gustavo Cordeiro de Faria Street, Natal 59012-570, RN, Brazil.
Department of Immunology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife 50670-420, PE, Brazil.
出版信息
Int J Mol Sci. 2023 Jul 28;24(15):12112. doi: 10.3390/ijms241512112.
This study aimed to evaluate seed oil with or without resveratrol entrapped in organogel nanoparticles in vitro against A375 human melanoma tumor cells. Organogel nanoparticles with seed oil (SON) or with resveratrol entrapped in the seed oil (RSON) formed functional organogel nanoparticles that showed a particle size <100 nm, polydispersity index <0.3, negative zeta potential, and maintenance of electrical conductivity. The resveratrol entrapment efficiency in RSON was 99 ± 1%. The seed oil and SON showed no cytotoxicity against human non-tumor cells or tumor cells. Resveratrol at 50 μg/mL was cytotoxic for non-tumor cells, and was cytotoxic for tumor cells at 25 μg/mL. Resveratrol entrapped in RSON showed a decrease in cytotoxicity against non-tumor cells and cytotoxic against tumor cells at 50 μg/mL. Thus, SON is a potential new platform for the delivery of resveratrol with selective cytotoxic activity in the treatment of melanoma.
本研究旨在评估包载于有机凝胶纳米粒中的种子油（无论是否含有白藜芦醇）对A375人黑色素瘤肿瘤细胞的体外作用。含有种子油的有机凝胶纳米粒（SON）或包载于种子油中的白藜芦醇（RSON）形成了功能性有机凝胶纳米粒，其粒径<100 nm，多分散指数<0.3，zeta电位为负，并保持了电导率。RSON中白藜芦醇的包封率为99±1%。种子油和SON对人非肿瘤细胞或肿瘤细胞均无细胞毒性。50 μg/mL的白藜芦醇对非肿瘤细胞具有细胞毒性，对肿瘤细胞在25 μg/mL时具有细胞毒性。包载于RSON中的白藜芦醇对非肿瘤细胞的细胞毒性降低，在50 μg/mL时对肿瘤细胞具有细胞毒性。因此，SON是一种潜在的新平台，可用于递送具有选择性细胞毒性活性的白藜芦醇以治疗黑色素瘤。
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