Department of Obstetrics and Gynecology, University Erlangen, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Int J Mol Sci. 2023 Aug 2;24(15):12353. doi: 10.3390/ijms241512353.
Endometrial cancer and uterine sarcoma represent the two major types of uterine cancer. In advanced stages, both cancer entities are challenging to treat and correlate with a meagre survival and prognosis. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is a form of localized chemotherapy that is heated to improve the chemotherapeutic effect on peritoneal metastases. The aim of the current review is to study the role of HIPEC in the treatment of uterine cancer. A literature review was conducted using the MEDLINE and LIVIVO databases with a view to identifying relevant studies. By employing the search terms "hyperthermic intraperitoneal chemotherapy", "uterine cancer", "endometrial cancer", and/or "uterine sarcoma", we managed to identify 26 studies published between 2004 and 2023. The present work embodies the most up-to-date, comprehensive review of the literature centering on the particular role of HIPEC as treatment modality for peritoneally metastasized uterine cancer. Patients treated with cytoreductive surgery, alongside HIPEC, seem to profit from not only higher survival but also lower recurrence rates. Factors such as the completeness of cytoreductive surgery, the peritoneal cancer index, the histologic subtype, or the applied chemotherapeutic agent, all influence HIPEC therapy effectiveness. In summary, HIPEC seems to represent a promising treatment alternative for aggressive uterine cancer.
子宫内膜癌和子宫肉瘤是两种主要的子宫癌类型。在晚期，这两种癌症都难以治疗，且生存率和预后都较差。腹腔内热灌注化疗（HIPEC）是一种局部化疗形式，通过加热来提高对腹膜转移的化疗效果。本综述旨在研究 HIPEC 在子宫癌治疗中的作用。通过使用 MEDLINE 和 LIVIVO 数据库进行文献回顾，以确定相关研究。通过使用“腹腔内热灌注化疗”、“子宫癌”、“子宫内膜癌”和/或“子宫肉瘤”等搜索词，我们成功地找到了 2004 年至 2023 年期间发表的 26 项研究。本工作是目前为止关于 HIPEC 作为腹膜转移型子宫癌治疗方法的最新、最全面的文献综述。接受细胞减灭术联合 HIPEC 治疗的患者不仅生存率更高，而且复发率更低。细胞减灭术的完全程度、腹膜癌指数、组织学亚型或应用的化疗药物等因素都会影响 HIPEC 治疗的效果。总的来说，HIPEC 似乎是一种有前途的治疗侵袭性子宫癌的方法。
