WD 重复和 HMG 盒 DNA 结合蛋白 1：一种位于肿瘤发生中心的癌蛋白和一个新的治疗靶点。

Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, China.

Int J Mol Sci. 2023 Aug 6;24(15):12494. doi: 10.3390/ijms241512494.

WD repeat and HMG-box DNA binding protein 1 (WDHD1) is a highly conserved gene from yeast to humans. It actively participates in DNA replication, playing a crucial role in DNA damage repair and the cell cycle, contributing to centromere formation and sister chromosome segregation. Notably, several studies have implicated WDHD1 in the development and progression of diverse tumor types, including esophageal carcinoma, pulmonary carcinoma, and breast carcinoma. Additionally, the inhibitor of WDHD1 has been found to enhance radiation sensitivity, improve drug resistance, and significantly decrease tumor cell proliferation. This comprehensive review aims to provide an overview of the molecular structure, biological functions, and regulatory mechanisms of WDHD1 in tumors, thereby establishing a foundation for future investigations and potential clinical applications of WDHD1.

WD 重复和 HMG 盒 DNA 结合蛋白 1（WDHD1）是一个从酵母到人高度保守的基因。它积极参与 DNA 复制，在 DNA 损伤修复和细胞周期中发挥关键作用，有助于着丝粒形成和姐妹染色体分离。值得注意的是，多项研究表明 WDHD1 参与了多种肿瘤类型的发展和进展，包括食管癌、肺癌和乳腺癌。此外，已经发现 WDHD1 的抑制剂可以增强辐射敏感性，提高耐药性，并显著降低肿瘤细胞增殖。本综述旨在概述 WDHD1 在肿瘤中的分子结构、生物学功能和调节机制，为未来 WDHD1 的研究和潜在的临床应用奠定基础。